Abstract: Amphiphilic, polyhedron-shaped p-sulfonatocalix[4]arene building blocks, which have been shown previously to assemble into bilayers in an antiparallel fashion, assemble in a parallel alignment into spherical and helical tubular structures on the addition of pyridine N-oxide and lanthanide ions. The addition of greater amounts of pyridine N-oxide changed the curvature of the assembling surface and led to the formation of extended tubules. The inventive compositions and methods are useful for drug delivery and construction of nano-devices.
Type:
Grant
Filed:
August 11, 2000
Date of Patent:
December 17, 2002
Assignee:
The Curators of the University of Missouri
Inventors:
Jerry L. Atwood, G. William Orr, Leonard J. Barbour