Patents Represented by Attorney William E. Maycock
  • Patent number: 4105498
    Abstract: A deoxygenated, inert, oil-like fluid having an oxygen activity coefficient less than that of water may be used to provide anaerobic conditions for the transport and/or storage of anaerobic specimens.
    Type: Grant
    Filed: May 19, 1977
    Date of Patent: August 8, 1978
    Assignee: Corning Glass Works
    Inventors: William Hertl, William S. Ramsey
  • Patent number: 4102669
    Abstract: A class of 4-piperidinones and corresponding dihydropyridinones having a phenyl substituent at one .beta.-position, an alkyl, alkenyl or propargyl group at the 1-position and an optional substituent at the other .beta.-position are broad-spectrum herbicides. The compounds bear a metasubstituent on the phenyl ring, and are particularly suited for use as herbicides in cotton culture.
    Type: Grant
    Filed: August 18, 1977
    Date of Patent: July 25, 1978
    Assignee: Eli Lilly and Company
    Inventor: Harold Mellon Taylor
  • Patent number: 4098876
    Abstract: Method of determining the presence and/or concentration of a polyvalent antigenic substance in a fluid. The method comprises the steps of incubating the fluid with labeled antibodies to the substance to form a first labeled immunochemical complex and then incubating that complex with immobilized antibodies to the substance to form a second labeled complex which is separated from the incubation medium. The amount of label in the second complex provides a means for detecting and/or quantitating the substance in the fluid. By reversing the sequence of incubation steps in a "two-site" or sandwich assay, greater sensitivity is achieved and an intermediate washing step is eliminated.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: July 4, 1978
    Assignee: Corning Glass Works
    Inventors: Roger N. Piasio, James W. Ryan, James E. Woiszwillo
  • Patent number: 4084004
    Abstract: A group of diphenylamines, having trinitro substitution or dinitro-trifluoromethyl substitution on one ring and from 1 to 5 substituents of a defined class, particularly halogen atoms, on the other ring, are useful rodenticides.
    Type: Grant
    Filed: July 21, 1976
    Date of Patent: April 11, 1978
    Assignee: Eli Lilly and Company
    Inventor: Barry Allen Dreikorn
  • Patent number: 4083962
    Abstract: Synergistic coccidiocidal combinations comprise two ionophorous fermentation-derived coccidiocides, each of which is administered to poultry in a concentration too low to produce satisfactory coccidiocidal effect alone. Preferred combinations include monensin and A204, monensin and lasalocid, and monensin and A28086.
    Type: Grant
    Filed: March 14, 1977
    Date of Patent: April 11, 1978
    Assignee: Eli Lilly and Company
    Inventor: Larry R. McDougald
  • Patent number: 4075323
    Abstract: Synergistic coccidiocidal combinations comprise two ionophorous fermentation-derived coccidiocides, each of which is administered to poultry in a concentration too low to produce satisfactory coccidiocidal effect alone. Preferred combinations include monensin and A204, monensin and lasalocid, and monensin and A28086.
    Type: Grant
    Filed: March 25, 1976
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventor: Larry R. McDougald
  • Patent number: 4075218
    Abstract: A class of s-triazolo[5,1-b]benzothiazoles are disclosed and are shown to be useful for the control of foliage-consuming insects and fungi which attack the foliage of plants.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventor: Charles J. Paget
  • Patent number: 4075000
    Abstract: A class of 4-amino-3,3-dimethyl-1-phenyl-2-azetidinones reduce the vigor of unwanted herbaceous plants to which the compounds are applied. The compounds are effective when applied either preemergence or postemergence at rates from about 2 to about 20 kg./ha.
    Type: Grant
    Filed: May 27, 1975
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventor: Riaz F. Abdulla
  • Patent number: 4066776
    Abstract: Novel 1,4-disubstituted-3-nitropyrazoles having antimicrobial, parasiticidal, and herbicidal activity are prepared by a reaction sequence of which the individual steps are conventional. The new 3-nitropyrazoles are characterized by a 1-substituent and a usually carbonyl-containing 4-substituent. The novel 3(5)-nitro-4-pyrazole-carbonitrile is obtained as an intermediate in the preparation of the biologically-active compounds. Preferred compounds are 1-alkyl or -alkenyl-4-pyrazolecarboxamides and carbonitriles. The new compounds are particularly useful for the control of bacterial animal diseases.
    Type: Grant
    Filed: June 18, 1976
    Date of Patent: January 3, 1978
    Assignee: Eli Lilly and Company
    Inventors: Reuben G. Jones, Norman H. Terando
  • Patent number: 4065290
    Abstract: A class of 4-piperidinones and corresponding dihydropyridinones having a phenyl substituent at one .beta.-position, an alkyl, alkenyl or propargyl group at the 1-position and an optional substituent at the other .beta.-position are broad-spectrum herbicides. The compounds bear a meta-substituent on the phenyl ring, and are particularly suited for use as herbicides in cotton culture.
    Type: Grant
    Filed: May 20, 1976
    Date of Patent: December 27, 1977
    Assignee: Eli Lilly and Company
    Inventor: Harold Mellon Taylor
  • Patent number: 4065463
    Abstract: A small class of 2-methyl-4-phenyl-5-isoxazolinones are herbicides. The phenyl ring is substituted in the meta position. The compounds are particularly useful as pre-emergence herbicides.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: December 27, 1977
    Assignee: Eli Lilly and Company
    Inventors: James Richard Beck, Robert Peter Gajewski
  • Patent number: 4065559
    Abstract: A class of 2,6-dinitroanilines having a broad range of substituent groups on the anilino nitrogen and in the 3- and 4-positions of the phenyl ring are used for the protection of plants against soil-borne phytopathogens of the genus Phytophthora.
    Type: Grant
    Filed: March 19, 1976
    Date of Patent: December 27, 1977
    Assignee: Eli Lilly and Company
    Inventor: James D. Froyd
  • Patent number: 4061755
    Abstract: The combination of monensin and meticlorpindol is synergistically effective in the control of coccidiosis of poultry.
    Type: Grant
    Filed: March 25, 1976
    Date of Patent: December 6, 1977
    Assignee: Eli Lilly and Company
    Inventor: Larry R. McDougald
  • Patent number: 4048312
    Abstract: 2,4-Diaminoquinazolines are employed as antithrombotic agents and have the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 are monovalent groups independently selected from the group consisting ofA. ##STR2## wherein R.sub.4 and R.sub.5 independently are selected from the group consisting of hydrogen, alkyl, and cycloalkyl, with the proviso that both R.sub.4 and R.sub.5 cannot be cycloalkyl,B. ##STR3## wherein R.sub.6, R.sub.7, and R.sub.8 independently are selected from the group consisting of hydrogen and alkyl, and A is a divalent organic group having from two to about six carbon atoms such that the two nitrogen atoms are separated by at least two carbon atoms, andC. heterocyclic-amino, andR.sub.3 is a monovalent group selected from the group consisting of hydrogen, halogen, and alkyl.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: September 13, 1977
    Assignee: Eli Lilly and Company
    Inventor: William B. Lacefield
  • Patent number: 4033941
    Abstract: Glucagon is purified by gel filtration at a pH of from about 9 to about 11.
    Type: Grant
    Filed: December 17, 1975
    Date of Patent: July 5, 1977
    Assignee: Eli Lilly and Company
    Inventors: John G. Stilz, Richard L. Jackson
  • Patent number: 4031107
    Abstract: The present invention is a process for the introduction of a nucleophilic group into a benzimidazole or imidazo[4,5-b or c]pyridine ring, which comprises treating a derivative of the corresponding 1-hydroxybenzimidazole or -imidazo[4,5-b or c]pyridine with a nucleophilic reagent. The process can also be used to reduce the 1-hydroxybenzimidazole or -imidazo[4,5-b or c]pyridine.
    Type: Grant
    Filed: February 23, 1976
    Date of Patent: June 21, 1977
    Assignee: Eli Lilly and Company
    Inventor: George O. P. O'Doherty
  • Patent number: 4028090
    Abstract: A group of new 1,3,4-thiadiazol-2-ylureas are characterized by a cyanoalkyl group at the 5-position. The alkyl group to which the cyano group is attached is always branched, and is preferably branched at the carbon atom adjacent to the ring. The compounds are also characterized by small alkyl or alkoxy groups on the urea nitrogens. The new compounds are outstandingly effective herbicides and are also effective, when used at low application rates, in the control of plant pathogens.
    Type: Grant
    Filed: January 26, 1976
    Date of Patent: June 7, 1977
    Assignee: Eli Lilly and Company
    Inventor: Tony Cebalo
  • Patent number: 4027041
    Abstract: A method of treating vascular thrombosis in warm-blooded animals, employing an ethyl- or vinylbenzene as the active antithrombotic agent.
    Type: Grant
    Filed: May 26, 1976
    Date of Patent: May 31, 1977
    Assignee: Eli Lilly and Company
    Inventor: Erwin A. Stephan
  • Patent number: 4024284
    Abstract: A method of treating inflammation in warm-blooded animals, employing an ethyl- or vinylbenzene as the active anti-inflammatory agent.
    Type: Grant
    Filed: May 26, 1976
    Date of Patent: May 17, 1977
    Assignee: Eli Lilly and Company
    Inventor: Erwin A. Stephan
  • Patent number: 4021553
    Abstract: A method of treating inflammation which utilizes topically-active 5,6-diaryl-1,2,4-triazines having the formula, ##STR1## wherein R is hydrogen or --(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are C.sub.1 -C.sub.3 alkoxy or di(C.sub.1 -C.sub.3 alkyl)amino; and the pharmaceutically-acceptable acid addition salts of basic members thereof.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: May 3, 1977
    Assignee: Eli Lilly and Company
    Inventors: William B. Lacefield, Peter P. K. Ho