Abstract: The invention is directed to an aqueous non-ototoxic, topical, otic pharmaceutical composition of matter for treating a mammal consisting essentially of: ciprofloxacin or a pharmaceutically acceptable salt thereof in aqueous solution in an amount effective for antibacterial action; hydrocortisone or a pharmaceutically acceptable salt thereof in an amount effective as an anti-inflammatory agent; polyvinyl alcohol at least about 85% hydrolyzed in an amount effective to suspend the hydrocortisone in solution; water sufficient to produce an aqueous composition; benzyl alcohol in an amount effective for antibacterial action; lecithin in an amount effective for enhancing suspension of other constituents in the composition; and polysorbate ranging from polysorbate 20 to 80 in an amount effective for spreading the preparation on a hydrophobic skin surface to the site of infection or inflammation.

Abstract: Aspartyl protease inhibitors such as pepstatin A have been found to prevent dissemination of Candida species across an epithelial barrier in mammals. Accordingly, a method for reducing adverse biological effects of dissemination of Candida species in an immunosuppressed mammal comprises administering prophylactically to the mammal an effective amount of an inhibitor of an aspartyl protease.

Abstract: This invention concerns methods of treating mast-cell mediated conditions in mammals, the methods comprising administering to the mammals pharmacologically active fragments or muteins of SLPI; methods of treating asthma or allergic rhinitis in mammals, the methods comprising administering to the mammals SLPI or pharmacologically active fragments or muteins thereof; methods for inhibiting tryptase; methods for identifying inhibitors of tryptase; and certain fragments and muteins of SLPI.

Abstract: Silicone surfactants having a siloxane backbone and a mixture of high and low atomic mass oxyalkylene pendant groups, these polyether pendants having average atomic masses of 1500-6000 and 300-750 respectively. The surfactants of the invention operate in polyurethane foam compositions to provide stable foams over a range of surfactant concentrations while still producing product foams having relatively constant breathability. Also disclosed and claimed are polyurethane foam compositions which include the surfactants, a method of making polyurethane foam using the surfactants, and polyurethane foam made by the method.

Abstract: A surface coating composition and method for applying the same to inorganic substrates. The composition comprises a moisture-curable aqueous urethane dispersion, a cross-linking agent and an anionic surfactant, wherein the anionic surfactant has a phosphate group substituent. The aqueous urethane dispersion comprises discrete linear aliphatic urethane chains and the several chains are linked together upon curing.

Abstract: A process for producing a polymer crosslinkable by exposure to moisture in the presence of a hydrolysis/condensation catalyst comprising blending (i) a thermoplastic base polymer, (ii) a solid carrier polymer containing a silane, and (iii) a free radical generator; heating and mixing (i), (ii) and (iii) together at a temperature above the crystalline melting point of said base polymer; optionally, a free-radical generator, hydrolysis/condensation catalyst, and other additives are contained in the solid carrier polymer.

Abstract: A process for manufacture of molded, high resiliency, polyurethane foam substantially free of volatile organic blowing agents comprising feeding at least three streams into a mixing device to form a reaction mixture, wherein a first stream contains (i) a polyol, (ii) water, (iii) a catalyst, (iv) a surfactant; a second stream contains an organic polyisocyanate; and a third stream contains (i) water, (ii) a crosslinking/extending agent, and (iii) a process/foam modifier.

Abstract: A process for making flexible polyurethane foam, employing a silicone surfactant composition containing 5-20 wt % of a defined low molecular weight silicone surfactant and 95-80 wt % of a defined high molecular weight silicone surfactant. Use of the claimed mixture of surfactants provides product foams having improved breathability relative to foams produced using high molecular weight silicone surfactant alone.

Abstract: Novel compositions of silicone/polyether block copolymers are provided which are useful as surfactants in several classes of polyurethane foam production. While conventional copolymers have a polysiloxane backbone with pendant polyethers, the surfactants of the present invention are the reverse with siloxane pendants on a polyether chain. These novel non-hydrolyzable polysiloxane polyoxyalkylene copolymers which are characterized by an "inverted" structure, i.e., polyoxyalkylene backbones with lateral and/or terminally pendant polysiloxanes, represent species that are of a narrow molecular weight and compositional distribution and are free of unreacted polyether or non-modified silicone oil diluent. These surfactants are useful in various urethan foam systems and can also display aqueous wetting properties.

Abstract: Novel siloxane-polyether polymers are provided containing cyclic siloxanes which are useful in silicone surfactants for foam polyurethane foam applications. The novel polymers are prepared by reacting a polyhydridosiloxane polymer with a cyclic polysiloxane containing a vinyl group and with an allyl started polyoxyalkylene polymer in the presence of a platinum catalyst. The resulting polymeric products are highly potent and impart flat breathability profiles to foams when used as surfactants in their preparation.

Abstract: The present invention relates to olefin polymer compositions which can be extruded into film material characterized by improved stability and optical properties. In particular, this application is directed olefin polymer compositions containing specific polyorganosiloxanes bearing a hydroxyl functionality.