Patents Represented by Attorney William H. Nicholson

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  • Angiotensin II antagonists incorporating a substituted imidazo [1,2-b][1,2,4]triazole
    Patent number: 5187179
    Abstract: There are disclosed substituted imidazo[1,2-b][1,2,4]triazole derivatives of Formula I which are useful as angiotensin II antagonists.
    Type: Grant
    Filed: March 22, 1991
    Date of Patent: February 16, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Wallace T. Ashton, Steven M. Hutchins, Malcolm MacCoss
  • Imidazole angiotensin II antagonists incorporating a substituted benzyl element
    Patent number: 5183810
    Abstract: Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: February 2, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Arthur A. Patchett, David Hangauer, Thomas F. Walsh, Kenneth J. Fitch, Ralph A. Rivero, Daljit S. Dhanoa
  • Recessed tip fluid dispenser
    Patent number: 5178613
    Abstract: A dispenser for liquids, e.g., ophthalmic liquids, is provided with a movable top that rotates to uncover an aperture and to expose a recessed dispensing tip.
    Type: Grant
    Filed: September 18, 1991
    Date of Patent: January 12, 1993
    Assignee: Merck & Co., Inc.
    Inventor: Kenneth J. Gibilisco
  • Angiotensin II antagonists incorporating a substituted thiophene or furan
    Patent number: 5177074
    Abstract: There are disclosed substituted thiophene and furan derivatives of Formula I which are useful as angiotensin II antagonists.
    Type: Grant
    Filed: March 11, 1992
    Date of Patent: January 5, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Eric E. Allen, Ralph A. Rivero, Nancy Kevin
  • Triazole angiotensin II antagonists incorporating a substituted benzyl element
    Patent number: 5177095
    Abstract: Substituted triazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: January 5, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Arthur A. Patchett, David Hangauer, Wallace Ashton, Kenneth J. Fitch, Thomas F. Walsh, Ralph A. Rivero, Daljit S. Dhanoa
  • Angiotensin II antagonists incorporating a substituted indole or dihydroindole
    Patent number: 5175164
    Abstract: Substituted heterocycles attached through a methylene bridge to novel substituted indole or dihydroindole derivative of the Formula I are useful as angiotensin II antagonists.
    Type: Grant
    Filed: June 5, 1991
    Date of Patent: December 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Scott Bagley, William J. Greenlee, Daljit S. Dhanoa, Arthur A. Patchett
  • Tricyclic thienothiopyrans as pharmaceutical intermediates
    Patent number: 5175284
    Abstract: Intermediates are described for preparing conformationally constrained tricyclic thienothiopyran compounds that are topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma associated therewith.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: December 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello, Kenneth L. Shepard, Theresa M. Williams
  • Substituted pyrimidines, pyrimidinones and pyridopyrimidines
    Patent number: 5166206
    Abstract: Substituted pyrimidines, pyrimidinones and pyridopyrimidines of formula (I) are as angiotensin II antagonists useful in the treatment of hypertension, ocular hypertension and certain CNS ailments: ##STR1## wherein K is --N(R.sup.8a)--C(.dbd.M) or --N.dbd.C(R.sup.8b) where M is O or NR.sup.22.
    Type: Grant
    Filed: March 27, 1991
    Date of Patent: November 24, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Eric E. Allen, William J. Greenlee, Malcolm MacCoss, Arthur A. Patchett
  • Pharmaceutical container
    Patent number: 5165546
    Abstract: A plastic pharmaceutical container is provided with a removable bottom section defining a cavity adapted to hold the package circular.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: November 24, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Arthur L. Jaeger, James M. Mundt
  • Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin II antagonsists
    Patent number: 5164407
    Abstract: There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: November 17, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, David B. R. Johnston, Malcolm MacCoss, Nathan B. Mantlo, Arthur A. Patchett, Prasun K. Chakravarty, Thomas F. Walsh
  • Angiotensin II antagonists incorporating a substituted benzyl element
    Patent number: 5162325
    Abstract: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists.
    Type: Grant
    Filed: May 7, 1991
    Date of Patent: November 10, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, Malcolm MacCoss, Nathan Mantlo, Thomas F. Walsh
  • Substituted 1-(2H)-isoquinolinones bearing acidic functional groups as angiotensin II antagonists
    Patent number: 5162340
    Abstract: Substituted 1-(2H)-isoquinolinones of the structural formula: ##STR1## are angiotensin II antagonists which are useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: November 10, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, Dooseop Kim
  • Dispensing bottle with internal flow rate restriction system
    Patent number: 5158213
    Abstract: A sterile packaging assembly (100) for dispensing a liquid in drops comprises a main body (101) of plastic material, having a top portion (103) with an outside thread for receiving a screw cap (104), and containing a flow rate restriction system (105) for controlling drop formation. The flow rate restriction system is positioned substantially on the axis of the main body and is held in position by a constricted portion (106) of the top portion (103) of the main body. The invention is particularly applicable to sterile packaging of pharmaceutical substances such as eye drops.
    Type: Grant
    Filed: October 24, 1990
    Date of Patent: October 27, 1992
    Assignee: Laboratoires Merck Sharp & Dohme-Chibret
    Inventor: Gilbert Lataix
  • Dispensing bottle with coupling between closure head and screw cap
    Patent number: 5158192
    Abstract: A sterile packaging assembly (100) for dispensing a liquid in drops comprises a main body (101) of plastic material, having a top portion (103) with an outside thread for receiving a screw cap (104), the top portion ending in an elongate neck, constituting a dispensing portion which is surmounted by a closure head (110) that can be torn off in order to define a dispensing orifice (111) on first utilization of the packaging assembly. The invention is particularly applicable to sterile packaging of pharmaceutical substances such as eye drops.
    Type: Grant
    Filed: October 24, 1990
    Date of Patent: October 27, 1992
    Assignee: Laboratoires Merck Sharp & Dohme-Chibret
    Inventor: Gilbert Lataix
  • Substituted quinolines as angiotensin II antagonists
    Patent number: 5157040
    Abstract: Substituted quinolines of the formula (I), are angiotensin II antagonists, ##STR1## and useful in the treatment of hypertension, ocular hypertension and certain CNS disorders.
    Type: Grant
    Filed: April 5, 1991
    Date of Patent: October 20, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, David B. R. Johnston, Malcolm MacCoss
  • Oxo-purines as angiotensin II antagonists
    Patent number: 5157026
    Abstract: Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: October 20, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, Thomas F. Walsh
  • Method to reduce introacular pressure without causing miosis
    Patent number: 5153205
    Abstract: Topical administration of a cholinomimetic agent, such as pilocarpine, in combination with a cholinergic M.sub.3 receptor antagonist, such as 4-diphenyl-acetoxy-N-methylpiperidine, to the eye of a mammal reduces intraocular pressure without the concommitant miotic effect that normally occurs with administration of a cholinomimetic agent along.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: October 6, 1992
    Assignee: Merck & Co., Inc.
    Inventor: Victor J. Lotti
  • Angiotensin II antagonists incorporating an indole or dihydroindole
    Patent number: 5151435
    Abstract: There are disclosed substituted indoles and dihydroindoles of Formula I which are useful as angiotensin II antagonists.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: September 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Scott Bagley, William J. Greenlee, Daljit S. Dhanoa, Arthur A. Patchett
  • Humoral hypercalcemic factor antagonists
    Patent number: 5149779
    Abstract: Peptide analogues of human humoral hypercalcemic factor (hHCF) that contain a lactam bridge act as inhibitors of the naturally occurring peptide. A lactam bridge between Lys and Asp situated five residues (inclusive) apart confers rigidity to that region of the peptide, and enhances the helical nature and metabolic stability of the peptide analogue.
    Type: Grant
    Filed: July 26, 1990
    Date of Patent: September 22, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Michael Chorev, Eli Roubini
  • Squalene synthetase inhibitors
    Patent number: 5135935
    Abstract: Compounds of structural formula (I): ##STR1## are squalene synthestase inhibitors useful in inhibiting the biosynthesis of cholesterol in the treatment of hypercholesterolemia and related disorders.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: August 4, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Alfred W. Alberts, Gregory D. Berger, James D. Bergstrom