Abstract: Genes and polypeptides encoded thereby of human chondroitin 6-sulfotransferase are provided. Vectors and host cells comprising these genes and transgenic animals capable of expressing them are also provided. In addition, methods of identifying polymorphic chondroitin 6-sulfotransferase in humans and activators or inhibitors of this enzyme are provided.

Abstract: The present invention is directed to methods for restoring reading vision and increasing the amplitude of accommodation in presbyopic patients. The method involves topically administering to the patient an amount of a composition sufficient to inhibit acetylcholine esterase activity in the eye of the patient. The invention discloses dose ranges of acetylcholine esterase inhibitor in the composition used for restoring reading vision and increasing the amplitude of accommodation in presbyopic patients and successful correction of presbyopia in these patients. The methods disclosed herein are also used to treat other disorders such as dry eye syndrome, hyperopia, myopia, amblyopia, glaucoma and cataracts.

Abstract: Chimeric viral proteins and nucleic acid constructs that code for them and are useful as therapeutic agents.

Abstract: An assembly and method for mounting linear structures in locked longitudinal alignment, which includes retainer bars joinable to a bracket for mounting linear structures and a pin assembly having wedge pins protruding outwardly from a base wherein the wedge pins engage opposing apertures in a locked, spring-loaded interface tightened into alignment by a retainer screw. The locked interface between opposing edges of the wedge pin and the apertures impart strong resistance to displacement forces, thereby providing a system for joining and mounting permitting adjustment and alignment of independently suspended linear structures and subsequent tightening down of the linear structures.