Abstract: A class of 2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridine and 2,3,4,4a,5,6,7,11b-octahydro-1H-benzo[3,4]cyclohepta[1,2-c]pyridine derivatives are selective ligands at sigma recognition sites and are therefore useful in the treatment and/or prevention of psychiatric and/or gastrointestinal disorders.
Type:
Grant
Filed:
June 18, 1991
Date of Patent:
October 19, 1993
Assignee:
Merck Sharp & Dohme Limited
Inventors:
David C. Billington, Michael G. N. Russell
Abstract: Novel acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamides are useful for the topical treatment of elevated intraocular pressure in ophthalmic compositions including drops and inserts.
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