Abstract: Disclosed is a 6-mercapto-cyclodextrin derivative having a general formula (I, ) wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C1-6) alkylene, optionally substituted with 1-3 OH groups, or (CH2)o-phenylene-CH2)p—; o and p are independently 0-4; X is COOH, CONHR3, NHCOR2, SO2OH, PO(OH)2, O(CH2—CH2—O)q—H, OH or tetrazol-5-yl: R2 is H or (C1-3)alkyl; R2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.
Type:
Grant
Filed:
June 23, 2003
Date of Patent:
September 27, 2005
Assignee:
Akzo Nobel N.V.
Inventors:
Mingqiang Zhang, Ronald Palin, David Jonathan Bennett
Abstract: An improved device and method for packaging, transportation, or handling in storage of products and materials, and especially materials such as painted or powder coated products and powder materials. The invention is understood to relate to a container in the form of a cardboard box having a liner of geotextile fabric. Optionally, the box has an inner box sandwiching the liner between itself and the outer box.
Type:
Grant
Filed:
April 6, 1999
Date of Patent:
February 5, 2002
Inventors:
Richard Lee McCormick, Linda Dianne McCormick