Patents Represented by Attorney, Agent or Law Firm William R. Boudreaux
  • Piperidinyl thiacyclic derivatives
    Patent number: 5476861
    Abstract: Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: December 19, 1995
    Assignee: Merrell Dow Pharmaceuricals Inc.
    Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
  • Glucohydrolase inhibitors useful as antidiabetic agents
    Patent number: 5438069
    Abstract: The invention provides the compounds 1,2-dideoxy-2-(hydroxymethyl)-1-(methylamino)-myo-inositol hydrochloride, 1,2-dideoxy-2-(hydroxymethyl)-1-(methylamino)-scyllo-inositol, 1,6-dideoxy-6-(hydroxymethyl)-1-(methylamino)-myo-inositol.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: August 1, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert A. Farr, Norton P. Peet
  • Polyfluorinated tripeptide thrombin inhibitors
    Patent number: 5391705
    Abstract: This invention relates to novel polyfluorinated alkyl derivatives of certain tripeptides, to the methods for their preparation, the intermediates therefore, to their use in inhibiting thrombin and lung tryptase and in their end-use application as anti-coagulants useful in treating thrombophlebitis and coronary thrombosis and in the treatment of asthma.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: February 21, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Bernhard Neises, Axel Ganzhorn, Celine Tarnus, Robert J. Broersma, Jr.
  • Alpha-mannosidase and fucosidase inhibitors
    Patent number: 5382709
    Abstract: Substituted (1.alpha., 2.beta., 3.alpha. or .beta.,4.alpha.,5.alpha. or .beta.)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclopentylamines are inhibitors of alphamannosidase and alpha-fucosidase and are useful immunostimulants, antiviral and antimetastatic agents.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: January 17, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert A. Farr, Norton P. Peet
  • Piperidinyl thiacyclic derivatives
    Patent number: 5371093
    Abstract: Piperidinyl thiacyclic derivatives ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: December 6, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, George D. Maynard, John M. Kane, Hsien C. Cheng, Mark W. Dudley
  • Sulfonic acid derivatives in the treatment of viral diseases
    Patent number: 5359131
    Abstract: Sulfonic acid stilbenes are disclosed which block the infection of cells by HSV, HIV and CMV.
    Type: Grant
    Filed: August 13, 1993
    Date of Patent: October 25, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Alan D. Cardin, Norton P. Peet, Nelsen L. Lentz
  • Method for producing an orexigenic effect
    Patent number: 5352686
    Abstract: The present invention is directed to the use of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and hexahydro-8-hydroxy-2,6-methano-2H-quinolizines in the manufacture of a medicament for producing an orexigenic effect.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: October 4, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: John T. Burke
  • Antithrombotic compounds
    Patent number: 5292752
    Abstract: The present invention is directed to a new class of piperidinyl medicinal agents which are useful as antithrombotic agents and as serotonin 5HT.sub.2 antagonists.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: March 8, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, John E. Koerner, Tung Li, Francis P. Miller, Thaddeus R. Nieduzak
  • Fluorinated arachidonic acid derivatives
    Patent number: 5225429
    Abstract: Fluorinated arachidonic derivatives are 5-lipoxygenase inhibitors which have the useful pharmacologic activity as antiallergy and anti-inflammatory agents and are useful for treating, for example, asthma, anaphylaxis, allergy, rheumatoid arthritis, and psoriasis and cardiovascular diseases.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: July 6, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jean-Bernard Ducep, Jean-Francois Nave, Detlef Jacobi