Patents Represented by Attorney, Agent or Law Firm Wilson Sonsini Goodrich and Rosati
  • Methods and systems of online mapping and planning driving tours
    Patent number: 8166410
    Abstract: This invention is directed to methods and systems of online mapping and planning driving tours. The invention may include a user interface capable of displaying a map with one or more destinations and/or displaying a travel route to visit each destination. The travel route may vary based on customizable options. The invention may also provide a tour summary that may show the driving directions for the travel route.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: April 24, 2012
    Assignee: MLSListings Inc.
    Inventors: Frank Tadman, Evelyn Horng
  • Magnesium compositions and uses thereof for metabolic disorders
    Patent number: 8163301
    Abstract: A composition for administration to a subject, such as oral administration to a subject, for example, has been provided. Such a composition may comprise at least one magnesium-counter ion compound. A magnesium-counter ion composition described herein may be useful for any of a variety of applications provided herein, such as maintaining, enhancing, and/or improving health, nutrition, and/or another condition of a subject, and/or cognitive, learning, and/or memory function. A magnesium-counter ion composition provided herein may be useful for administration to a subject presenting magnesium deficiency, mild cognitive impairment, Alzheimer's disease, attention deficit hyperactivity disorder, ALS, Parkinson's disease, diabetes, migraine, anxiety disorder, mood disorder, and/or hypertension. A kit, method, and other associated technology are also provided.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: April 24, 2012
    Assignee: Magceutics, Inc.
    Inventors: Guosong Liu, Fei Mao
  • Human trophoblast stem cells and use thereof
    Patent number: 8163553
    Abstract: Existence of human trophoblast stem (hTS) cells has been suspected but unproved. The isolation of hTS cells is reported in the early stage of chorionic villi by expressions of FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. hTS cells are able to derive into specific cell phenotypes of the three primitive embryonic layers, produce chimeric reactions in mice, and retain a normal karyotype and telomere length. In hTS cells, Oct4 and fgfr-2 expressions can be knockdown by bFGF. These facts suggest that differentiation of the hTS cells play an important role in implantation and placentation. hTS cells could be apply to human cell differentiation and for gene and cell-based therapies.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: April 24, 2012
    Inventors: Jau-Nan Lee, Tony Tung-Ying Lee, Yuta Lee
  • NS1-NP diagnostics of influenza virus infection
    Patent number: 8163474
    Abstract: The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many formats employ pan-specific antibodies (i.e., that react with all or at least with multiple strains within an influenza type).
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: April 24, 2012
    Assignee: Arbor Vita Corporation
    Inventors: Peter S. Lu, Michael P. Belmares, Carol Tan, Linda McAllister
  • Methods and systems for constraint of multiple spine segments
    Patent number: 8162982
    Abstract: Methods, apparatus and systems for constraining spinous processes to elastically limit flexion of two or more adjacent spinal segments rely on placing a tether structure over at least three adjacent vertebral bodies or two adjacent vertebral bodies and the sacrum. The tether structures may be continuous, for example in the form of a continuous loop, or may be discontinuous, for example in the form of a loop or elongate element having at least two anchor structures for securing in bone.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: April 24, 2012
    Assignee: Simpirica Spine, Inc.
    Inventors: Todd Alamin, Ian Bennett, Louis Fielding, Colin Cahill
  • Anchor post
    Patent number: 8156695
    Abstract: Provided herein are methods, devices and systems comprising an anchor post that has a shaft, at least one stabilizing element attached to the anchor post configured to resist movement of the anchor post, and at least one alignment element.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: April 17, 2012
    Assignee: Anchor Systems (Europe) Ltd.
    Inventor: Ewan R. Smith
  • Fluorescent methods and materials for directed biomarker signal amplification
    Patent number: 8158444
    Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
    Type: Grant
    Filed: October 8, 2007
    Date of Patent: April 17, 2012
    Assignee: Sirigen, Inc.
    Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, Cheng-Jun Sun, Russell Baldocchi
  • Inhibitors of Bruton's tyrosine kinase
    Patent number: 8158786
    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: April 17, 2012
    Assignee: Pharmacyclics, Inc.
    Inventors: Lee Honigberg, Erik Verner, Zhengying Pan
  • Systems and methods of fluidic sample processing
    Patent number: 8158430
    Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: April 17, 2012
    Assignee: Theranos, Inc.
    Inventors: Shaunak Roy, Malissa Takahashi, Ian Gibbons, Edmond Ku, Thanh Dang, Tammy Burd, Adam Vollmer, Elizabeth A. Holmes
  • Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
    Patent number: 8158647
    Abstract: Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein function as kinase modulators and have utility in the treatment of diseases such as cancer, allergy, asthma, inflammation, obstructive airway disease, autoimmune diseases, metabolic disease, infection, CNS disease, brain tumor, obesity, asthma, hematological disorder, degenerative neural disease, cardiovascular disease, or disease associated with angiogenesis, neovascularization, or vasculogenesis.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: April 17, 2012
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: Jeffrey M. Blaney, Andreas Gosberg, Stefan N. Gradl, Gavin Hirst, Stephanie A. Hopkins, Paul A. Sprengeler, Ruo W. Steensma, Johnny Uy
  • Treatment of rosacea with clostridia neurotoxins
    Patent number: 8153139
    Abstract: Methods of using clostridial toxins and other biological agents to treat rosacea in humans is provided. The disclosed methods provide beneficial effects in humans.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: April 10, 2012
    Inventors: Ira Sanders, Rosemary Aquila-Sanders
  • Purified amniotic membrane compositions and methods of use
    Patent number: 8153162
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: April 10, 2012
    Assignee: Tissuetech, Inc.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Method of improving the efficiency of loosely packed solar cells in dense array applications
    Patent number: 8153886
    Abstract: An increased efficiency Concentrator Photovoltaic System having a plurality of solar cells laterally spaced from each other on a substrate panel. The solar cells are mounted on electrically conductive areas of an otherwise non-conductive top surface of the substrate with each cell isolated from another by a non-conductive area. The individual cells are connected using ribbons or wires, between the front contact of the solar cells to the conductive area of another cell to form a circuit connecting the cells in a desired configuration. A plurality of tubular enclosures for concentrating light on the solar cells are mounted directly above the solar cells.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: April 10, 2012
    Assignee: Amonix, Inc.
    Inventors: Vahan Garboushian, Alexander M. Slade
  • Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    Patent number: 8153758
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: April 10, 2012
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman
  • Detection using a dye and a dye modifier
    Patent number: 8148515
    Abstract: The present invention relates to dyes in general. The present invention provides a wide range of dyes and kits containing the same, which are applicable for labeling a variety of biomolecules such as nucleic acids, cells and microorganisms. The present invention also provides various methods of using the dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: April 3, 2012
    Assignee: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung, Hye Eun Hoover
  • Method for ablating body tissue
    Patent number: 8146603
    Abstract: A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: April 3, 2012
    Assignee: VytronUS, Inc.
    Inventors: Hira V. Thapliyal, David A. Gallup, James W. Arenson
  • Transgene delivering retrovirus targeting collagen exposed at site of tissue injury
    Patent number: 8148509
    Abstract: A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: April 3, 2012
    Assignee: University of Southern California
    Inventors: Frederick L. Hall, Erlinda M. Gordon
  • Systems and methods for detection of session tampering and fraud prevention
    Patent number: 8151327
    Abstract: The invention provides methods and apparatus for detecting when an online session is compromised. A plurality of device fingerprints may be collected from a user computer that is associated with a designated Session ID. A server may include pages that are delivered to a user for viewing in a browser at which time device fingerprints and Session ID information are collected. By collecting device fingerprints and session information at several locations among the pages delivered by the server throughout an online session, and not only one time or at log-in, a comparison between the fingerprints in association with a Session ID can identify the likelihood of session tampering and man-in-the middle attacks.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: April 3, 2012
    Assignee: The 41st Parameter, Inc.
    Inventor: Ori Eisen
  • Base for retrofit LED lighting device
    Patent number: 8147267
    Abstract: A modified screw-in (Edison) type base for LED lighting devices that enables directional LED devices to be used in existing sockets. A movable center contact in a standard Edison type threaded base that enables the base to be screwed into a socket to make electrical contact while allowing the base to be rotated at least a half turn to allow a directional LED device to be aimed were the light is desired. The modified screw-type base that has a movable mount enabling a directional LED device to be firmly screwed into a standard bulb socket, then rotated to aim the light where it is desired.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: April 3, 2012
    Assignee: Xeralux, Inc.
    Inventor: Stephen Paul Oster
  • Clamp
    Patent number: 8141858
    Abstract: A clamp adapted to be removably fixed to a further object. The clamp includes first and second clamp members, each being configured to apply a clamping force to the further object to which the clamp is removably fixed. One clamp actuator is adapted to drive movement of both the first and second clamp members with respect to each other along respective first and second axes. The first axis intersects the second axis.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: March 27, 2012
    Assignee: Prosurgics Limited
    Inventor: Stephen John Morfey