Abstract: A pharmaceutical formulation is provided for delivering paclitaxel in vivo comprising: water and micelles comprising paclitaxel and a pharmaceutically-acceptable, water-miscible solubilizer forming the micelles, the solubilizer selected from the group consisting of solubilizers having the general structures
R1COOR2, R1CONR2, and R1COR2,
wherein R1 is a hydrophobic C3-C50 alkane, alkene or alkyne and R2 is a hydrophilic moiety. The solubilizer is selected such that it does not have a pKa less than about 6.
Type:
Grant
Filed:
July 9, 2002
Date of Patent:
January 21, 2003
Assignee:
SuperGen, Inc.
Inventors:
Rajashree Joshi-Hangal, Ashok Y. Gore, Joseph Rubinfeld, Rajesh Shrotriya