Patents Represented by Attorney Wilson Sonsini Goodrich & Rosati

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  • Compounds, compositions and methods of using same for modulating uric acid levels
    Patent number: 8242154
    Abstract: Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: August 14, 2012
    Assignee: Ardea Biosciences, Inc.
    Inventors: Esmir Gunic, Jean-Luc Girardet, Jean-Michel Vernier, Martina E. Tedder, David A. Paisner
  • Methods of monitoring conditions by sequence analysis
    Patent number: 8236503
    Abstract: There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions. Identified biomarkers can be used to determine the disease state for a subject with an autoimmune disease or other condition.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: August 7, 2012
    Assignee: Sequenta, Inc.
    Inventors: Malek Faham, Thomas Willis
  • Methods for arterio-venous fistula creation
    Patent number: 8236014
    Abstract: Methods are disclosed for the formation of arterio-venous fistula creation. Embodiments include a femoral access approach to the creation of an Aorta-caval fistula at the bifurcation of the Aorta and the Inferior Vena Cava; an apparatus for the creation, modification and maintenance of a fistula; and a method of supplying oxygenated blood to the venous circulation of a patient. The devices, systems and methods can be used to treat patients with one or more numerous ailments including chronic obstructive pulmonary disease, congestive heart failure, hypertension, hypotension, respiratory failure, pulmonary arterial hypertension, lung fibrosis and adult respiratory distress syndrome.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: August 7, 2012
    Assignee: Rox Medical, Inc.
    Inventors: Rodney Brenneman, Douglas S. Cali, J. Christopher Flaherty
  • Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts
    Patent number: 8236338
    Abstract: Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: August 7, 2012
    Assignee: The University of Tennessee Research Foundation
    Inventors: Omran R. Abul-Khoudoud, Catherine Cagiannos, Waldemar G. DeRijk, Timothy C. Fabian, Lisa Kyle Jennings
  • Inhibitors of bruton's tyrosine kinase
    Patent number: 8236812
    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: August 7, 2012
    Assignee: Pharmacyclics, Inc.
    Inventors: Lee Honigberg, Erik Verner, Zhengying Pan
  • Melanin modification compositions and methods of use
    Patent number: 8236288
    Abstract: A method for the modification of melanin distribution, and the composition thereof to modify melanin distribution are disclosed. A method for the reduction of melanin distribution, and the composition thereof to reduce melanin distribution are disclosed. A representative composition comprises 4-ethoxybenzaldehyde and one or more additional active agents as well as a pharmaceutically acceptable carrier or excipient. Carriers and excipients may be formulated for topical administration. Compositions may also be formulated for transdermal administration. The compositions may be used for the prevention and treatment of pigmentation disorders, by way of non-limited example, post-inflammatory hyperpigmentation and others. The compositions may be used for lightening skin.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: August 7, 2012
    Assignee: Skinmedica, Inc.
    Inventors: Rahul C. Mehta, Elizabeth Tsin Ho Makino, Sujatha D. Sonti, John A. Garruto
  • Systems and methods for varying elastic modulus appliances
    Patent number: 8235713
    Abstract: The present invention provides improved devices, systems and methods for repositioning teeth from an initial tooth arrangement to a final tooth arrangement. Repositioning is accomplished with a system comprising a series of polymeric shell appliances configured to receive the teeth and incrementally reposition individual teeth in a series of successive steps. The individual appliances may be formed from layers having different stiffnesses (elastic moduluses), and the stiffnesses of successive appliances may be different, or both.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: August 7, 2012
    Assignee: Align Technology, Inc.
    Inventors: Loc X. Phan, Muhammad Chishti, Ross J. Miller, H. Robert Vandenberg, Eric Kuo
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 8232384
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: July 31, 2012
    Assignee: University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Quantification of non-reducing end glycan residual compounds
    Patent number: 8232073
    Abstract: Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: July 31, 2012
    Assignee: Zacharon Pharmaceuticals, Inc.
    Inventors: Brett E. Crawford, Jillian R. Brown, Charles A. Glass, Jim R. Beitel, Robin M. Jackman
  • Chlorite formulations and methods of preparation and use thereof
    Patent number: 8231856
    Abstract: Described herein are chlorite formulations having a pH between about 7 and about 8.5, wherein the chlorite formulations are substantially free of deleterious non-chlorite components. Described herein are chlorite formulations, including pharmaceutical formulations, which are formulated for systemic, parenteral, or intravenous administration. Described herein are methods of preparing and methods of using the chlorite formulations described herein.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: July 31, 2012
    Assignee: Neuraltus Pharmaceuticals, Inc.
    Inventors: William Boulanger, Arasteh Ari Azhir
  • Inhibitors of bruton'S tyrosine kinase
    Patent number: 8232280
    Abstract: Disclosed herein are pyrazolo[3,4-d]pyrimidines that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: July 31, 2012
    Assignee: Pharmacyclics, Inc.
    Inventors: Lee Honigberg, Erik Verner, Zhengying Pan
  • Compositions for delivery of therapeutics and other materials
    Patent number: 8231859
    Abstract: This disclosure relates to compositions for delivering agents to a subject, and in particular, to compositions for delivery of therapeutic agents or diagnostic agents in the presence or absence of targeting moieties. In part, this disclosure relates to compositions comprising a hydrophobic group with a first end and a second end, a first metal binding domain linked to the hydrophobic group, a metal ion capable of being chelated to the first metal binding domain, and an agent linked to a second metal binding domain capable of chelating to the metal ion.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: July 31, 2012
    Assignee: PharmaIN Corporation
    Inventors: Elijah M. Bolotin, Gerardo M. Castillo
  • Methods of using dyes in association with nucleic acid staining or detection and associated technology
    Patent number: 8232050
    Abstract: Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: July 31, 2012
    Assignee: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung
  • Methods for diagnosis, prognosis and methods of treatment
    Patent number: 8227202
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: July 24, 2012
    Assignee: Nodality, Inc.
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
  • Diaryl-purines, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitor for treatment of HIV
    Patent number: 8227601
    Abstract: This application concerns certain 2-phenylamino-6-aryl amino-, 6-aryloxy-, and 6-arylthio-purines, -azapurines and -deazapurines. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: July 24, 2012
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung-Hyo Koh, Stephanie Shaw, Hong Woo Kim, Zhi Hong
  • Stabilization of unstable space debris
    Patent number: 8226046
    Abstract: Disclosed herein, in certain embodiments, is a method of altering the stability of unstable space debris. In some embodiments, the method further comprises changing the orbit of the unstable space debris.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: July 24, 2012
    Assignee: Poulos Air & Space
    Inventor: Dennis Poulos
  • Endoglin antibodies
    Patent number: 8221753
    Abstract: The present application relates to compositions of humanized and humanized/deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One aspect relates to antibodies having one or more modifications in at least one amino acid residue of at least one of the framework regions of the variable heavy chain, the variable light chain or both. Another aspect relates to antibodies which bind endoglin and inhibit angiogenesis. Another aspect relates to the deimmunization of humanized antibodies to reduce immunogenicity. Another aspect relates to the use of humanized and humanized/deimmunized antibodies which bind endoglin for the detection, diagnosis or treatment of a disease or condition associated with endoglin, angiogenesis or a combination thereof.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: July 17, 2012
    Assignee: Tracon Pharmaceuticals, Inc.
    Inventors: Charles Theuer, Maximiliano Vasquez
  • Electrosurgical ablation apparatus and method
    Patent number: 8221404
    Abstract: The present invention relates to the field of electrosurgery, and more particularly to a system that produces a focused plasma for tissue ablation. The system includes a probe and a remote source of a conductive liquid media for providing a flow through the probe that functions as an electrode. A pressurized flow of the liquid media passes through a first larger diameter flow channel in the probe to then increases in velocity as it passes through a smaller diameter flow restriction channel in a working end surface. The flow restriction of the liquid electrode through the flow restriction channel when coupled with high frequency voltage causes instantaneous ignition of a plasma within media flow media within the flow restriction channel. The working end surface thus carries a plasma that when proximate to tissue will cause a controlled, focused ablation.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: July 17, 2012
    Assignee: ARQOS Surgical, Inc.
    Inventor: Csaba Truckai
  • Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
    Patent number: 8221995
    Abstract: The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an immunoassay for CCL23 splice variant.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 17, 2012
    Inventors: Seok-Won Lee, Kelline M. Rodems, David W. Oelschlager, Uday Kumar Veeramallu, Joseph A. Buechler, Paul H. McPherson
  • Air collector with functionalized ion exchange membrane for capturing ambient CO
    Patent number: 8221527
    Abstract: An apparatus for capture of CO2 from the atmosphere comprising an anion exchange material formed in a matrix exposed to a flow of the air.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: July 17, 2012
    Assignee: Kilimanjaro Energy, Inc.
    Inventors: Allen B. Wright, Eddy J. Peters