Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
Type:
Grant
Filed:
February 29, 2008
Date of Patent:
September 1, 2009
Assignee:
SGX Pharmaceuticals, Inc.
Inventors:
William D. Arnold, Pierre-Yves Bounaud, Andreas Gosberg, Zhe Li Bounaud, Ian McDonald, Ruo W. Steensma, Mark E. Wilson
Abstract: Pharmaceutical formulations, kits and vessels are provided for delivering decitabine to a patient suffering from a disease in need of treatment with decitabine. The pharmaceutical formulation comprises decitabine solvated in a non-aqueous solvent that comprises glycerin, propylene glycol, polyethylene glycol, or combinations. Such formulations are more chemically stable than conventional liquid formulations of decitabine containing more than 40% water in volume. The pharmaceutical formulations can be used for any disease that is sensitive to the treatment with decitabine, such as hematological disorders and cancer.
Type:
Grant
Filed:
July 13, 2004
Date of Patent:
November 14, 2006
Assignee:
SuperGen, Inc.
Inventors:
Rajashree Joshi-Hangal, Xichen Zhang, Stephanie Gong, Sanjeev Redkar, Ashok Y. Gore