Patents Represented by Attorney, Agent or Law Firm Woddock Washburn LLP
  • Regioselective synthesis of 2?-O-modified nucleosides
    Patent number: 6624294
    Abstract: Methods for the regioselective alkylation at the 2′-hydroxy position over the 3′-hydroxy position of nucleosides and nucleoside analogs, forming 2′-O-ester modified compounds, are disclosed. Reduction and derivatization of the 2′-O-ester provides 2′-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: September 23, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Andrew M. Kawasaki, Allister S. Fraser, Muthiah Manoharan, P. Dan Cook, Thazha P. Prakash