Abstract: Methods and compositions for treating inflammatory and proliferative diseases, enabling treatment of MDR tumor cells by using combination of compounds, or a bifunctional compound, that inhibits both fatty acid metabolism and glycolysis. In particular, the invention combines or links a glycolysis inhibitor that is, or that is derived from, hypoglycin A (also referred to as hypoglycine A) and a fatty acid metabolism inhibitor. Preferably, the invention provides bifunctional compounds that link a moiety having the functionality of an oxirane carboxylic acid compound to a moiety having the functionality a hypoglycin A derivative. In specific embodiments, the invention provides a bifunctional compound that links a moiety having the functionality of etomoxir to a moiety having the functionality of hypoglycin A.

Abstract: An electronic charge retention circuit for time measurement, including: at least a first capacitive element, a first electrode of which is connected to a floating node (F); at least a second capacitive element, a first electrode of which is connected to the floating node, the first capacitive element having a leakage through its dielectric space and the second capacitive element having a capacitance greater than the first; and at least a first transistor having an isolated control terminal connected to the floating node.

Abstract: A system and method for controlling operation of a transducer circuit, e.g., including an acoustic transducer arranged to cause mixing, cavitation or other movement in a liquid contained in a vessel located remote from the transducer. A load current of a transformer used to generate a drive signal for the transducer may be controlled to vary sinusoidally, to vary between negative and positive values and such that the load current flows in a closed loop when a zero voltage bias is applied across the primary transformer winding, to have a reduced or eliminated 3rd harmonic mode and/or to vary between three discrete modes including a forward current mode, a zero voltage loop current mode, and a freewheel current mode. An inverter circuit may be used to control the load current, e.g., so that the load current flows in a closed loop during portions of the control cycle.

Abstract: Methods, apparatus, and computer program products for providing a context-based grammar for automatic speech recognition, including creating by a multimodal application a context, the context comprising words associated with user activity in the multimodal application, and supplementing by the multimodal application a grammar for automatic speech recognition in dependence upon the context.

Abstract: A container for use in processing a biopsy sample. Biopsy sample and materials are received within a sample processing area of the container. A semi-permeable barrier is positioned at a downstream portion of the sample processing area and prevents the prevent passage of the biopsy sample. A cap is positioned at the downstream side of the barrier, and holds fluids within the container.

Abstract: This invention relates to certain biologically active chemical compounds, such as benzoimidazolyl-pyrazine derivatives of formula (I) or pharmaceutically acceptable salts thereof. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

Abstract: This invention concerns a sofa which solves the problems of the prior art by providing a sofa that can easily be assembled or disassembled by the end consumer at home. The disassembled sofa can be stored in 3 flat boxes. Storage in the flat boxes not only helps the warehouse to store the sofa, but when the end user has purchased the sofa it is easier in such flat boxes to transport it to the location where it will be assembled. The way this invention accomplishes these results is as follows: The parts of the sofa can be broken down into three boxes. Chaise sections can be assembled by placing the seat back flat on the ground and placing the seat frame/arm upright on top of the seat back. A metal threaded rod is used to connect the seat frame and the seat back. A metal nut is used to secure the seat frame to the back using a wrench that comes provided in the package of the kit. The legs are then twisted onto the bottom of the seat frame.

Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps:—providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity,—providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity,—screening said at least one expression library with said antibody preparation,—identifying antigens which bind in said screening to antibodies in said antibody preparation,—screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen

Abstract: A relatively non-toxic desazadesferrithiocin analog having the formula (I): wherein: R1, R2, R4 and R5 may be the same or different and may be H, straight or branched chain alkyl having up to 14 carbon atoms, e.g., methyl, ethyl, propyl and butyl, or arylalkyl wherein the aryl portion is hydrocarbyl and the alkyl portion is straight or branched chain, the arylalkyl group having up to 14 carbon atoms, R2 optionally being alkoxy having up to 14 carbon atoms; R3 is [(CH2)n—O]x—[(CH2)n—O]y-alkyl; n is, independently, an integer from 1 to 8; x is an integer from 1 to 8; y is an integer from O to 8, and R3O may occupy any position on the phenyl ring except the 4-position, or a salt, hydrate or solvate thereof; and methods and compositions for treating the effects of trivalent metal, i.e., iron, overload.

Abstract: Articles, compositions, kits and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids, and an apolipoprotein may be bound to at least the outer surface of the shell. In some embodiments, the structures, when introduced to a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.

Abstract: A handsfree call apparatus includes: a speaker held in the vicinity of a user's ear by a holding unit with a speaker unit thereof not being attached to a baffle board so as to mix sounds emitted from the front and back of a diaphragm thereof; a microphone, which is provided to a region where sounds emitted from the front and back of the diaphragm of the speaker are mixed and canceled out, configured to collect the call voice of the user; an output unit configured to output a call voice signal of the user from the microphone to transmit this to a call partner; and an input unit configured to receive a call voice signal from the call partner to supply this to the speaker.

Abstract: A medical form is marked by a clinician during a patient/clinician encounter to generate a record with information related to a current complaint. The form is partitioned into several regions related to patient history, examination and medical decision, respectively. The form is automatically analyzed and using the locations of the marks on the form and a predetermined set of rules, a billing code is generated. The billing code determines the fee to be paid to the clinician or health provider.

Abstract: A method of speech synthesis can include automatically identifying spoken passages and non-spoken passages within a text source and converting the text source to speech by applying different voice configurations to different portions of text within the text source according to whether each portion of text was identified as a spoken passage or a non-spoken passage. The method further can include identifying the speaker and/or the gender of the speaker and applying different voice configurations according to the speaker identity and/or speaker gender.

Abstract: Disclosed is a positive resist processing liquid composition which is composed of an aqueous solution containing a quaternary ammonium hydroxide represented by the following general formula (I). In the formula, R1 and R3 independently represent a methyl group, and R2 represents an alkyl group having 12-18 carbon atoms.

Abstract: Cancer treatment with a combination of an Epidermal Growth Factor Receptor tyrosine kinase inhibitor and an Interleukin-6 inhibitor.

Abstract: A method for testing a memory device. The memory device includes a matrix of memory cells having a plurality of rows and columns; the matrix includes a plurality of rows of operative memory cells each one for storing a variable value and at least one row of auxiliary memory cells each one storing a fixed value. The memory device further includes writing circuitry for writing selected values into the operative memory cells, and reading circuitry for reading the values being stored from the operative or auxiliary memory cells. The method includes reading output values from the row of auxiliary memory cells, determining a malfunctioning of the memory device in response to a missing match of the output values with the fixed values, determining a cause of the malfunctioning according to a pattern of reading errors between the output values and the corresponding fixed values, and providing a signal indicative of the cause of the malfunctioning.

Abstract: A disc changer includes a disc cartridge having an insertion hole, a case body into which the disc cartridge is inserted, having first and second shells which can be separated in which a plurality of disc-shaped recording media are storable by being arrayed in the axial direction of the center axis, and a lock lever for locking the shells in a connected state; and a disc holder to hold the inserted disc cartridge, including an unlocking piece which unlocks locking between the shells by being inserted into the insertion hole when the disc cartridge is inserted into the disc holder to press the lock lever, and a restricting lever supported by the unlocking piece, including a restricting portion engaged with the case body when the unlocking piece is inserted into the insertion hole, so that locking between the shells is unlocked, the restricting lever restricting movement in the extracting direction.

Abstract: An image browsing apparatus has: a display unit for displaying image data; a reproducing unit for reproducing audio data; a detector for detecting a feature of the audio data reproduced by the reproducing unit; and a controller for, when predetermined audio data is reproduced by the reproducing unit, controlling an updating interval of the image data displayed to the display unit on the basis of the feature of the predetermined audio data detected by the detector.