Abstract: Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration and/or functional repair of articular cartilage tissue.
Type:
Grant
Filed:
December 17, 2008
Date of Patent:
November 30, 2010
Assignee:
Genetics Institute, LLC
Inventors:
Renwen Zhang, Diane Peluso, Elisabeth Morris