Patents Represented by Attorney Yonggang Ji
  • Patent number: 8309055
    Abstract: The invention relates to novel 18F-labelled compounds which may be suitable for use as Positron Emission Tomography (PET) radiotracers, and to processes for preparation of such. The 18F-labelled compounds of the invention comprise a [18F]fluoroalkenyl group.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: November 13, 2012
    Assignee: Hammersmith Imanet Limited
    Inventors: Erik Arstad, Edward George Robins
  • Patent number: 8309770
    Abstract: A method of preparing novel [11C]-labeled benzophenone/bezoxazole analogues is provided. The present invention also provides novel [11C]-labeled benzophenone/bezoxazole analogues prepared from the GMP synthesis method. Kit claims for preparing novel [11C]-labeled benzophenone/bezoxazole analogues and a method of use thereof are also provided.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: November 13, 2012
    Assignee: GE Healthcare Limited
    Inventors: Farhad Karimi, Bengt Langstrom
  • Patent number: 8282888
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: October 9, 2012
    Assignee: GE Healthcare Limited
    Inventors: Tor Kihlberg, Oleksiy Itsenko, Tommy Ferm, Bengt Langstrom
  • Patent number: 8206571
    Abstract: The present invention claims a method for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. The present invention also provides for an apparatus for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. Kit claims for formation of [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species are also provided.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: June 26, 2012
    Assignee: GE Healthcare Limited
    Inventor: Alan Peter Clarke
  • Patent number: 8197793
    Abstract: The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: June 12, 2012
    Assignee: GE Healthcare AS
    Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Maduabuchi Arukwe, Hege Karlsen, Matthias Eberhard Glaser
  • Patent number: 8007766
    Abstract: The present invention relates to a method of producing radiolabelled gallium complexes that could be used as diagnostic agents, e.g. for positron emission tomography (PET) imaging.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: August 30, 2011
    Assignee: GE Healthcare Limited
    Inventors: Irina Velikyan, Bengt Langstrom
  • Patent number: 7994134
    Abstract: The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: August 9, 2011
    Assignee: GE Healthcare AS
    Inventors: Alan Cuthbertson, Bård Indrevoll, Magne Solbakken, Torgrim Engell, Colin Mill Archer, Harry John Wadsworth
  • Patent number: 7989215
    Abstract: The present invention relates to methods and systems for adding a reagent to an analyte in a gel. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a gel to a second vessel, such as a microtitre plate. The invention is useful in the manipulation of biological molecules such as nucleic acids, carbohydrates, proteins and peptides. In particular, the invention has utility for manipulating proteins and peptides in isoelectric focusing gels.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: August 2, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Jonas Astrom, Bengt Bjellqvist, Lars Fagerstam, Kristina Uhlen
  • Patent number: 7988858
    Abstract: The present invention relates to a method for generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of (a) providing at least one scaffold defined by the general formula (I): H2N—(X1)n—S—S—(X2)m—CH2—NH2 wherein X1 and X2 irrespective of each other are carbon atoms or heteroatoms, and n and m irrespective of each other are integers of 1 to 5; (b) providing at least one polydentate metal chelating affinity ligand arm, optionally in a form wherein the metal chelating functionalities of at least one arm are protected, on each scaffold by derivatisation of the nucleophilic NH2 groups of the scaffold; (c) reducing the disulfide bond of the derivatised scaffold; and, if required (d) deprotecting the functionalities of the ligand arm(s) provided in step (b). In the most preferred embodiment, the reduction of the disulfide bond and the deprotection step is performed essentially simultaneously.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: August 2, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Andreas Axen, Jean-Luc Maloisel, John Clachan, Helena Lindgren, Anne Catharina Bergh
  • Patent number: 7978885
    Abstract: A method of analysing a plurality of biological entities using an imaging apparatus. The method comprises: providing a marker for said plurality of biological entities, said marker being capable of identifying objects within said plurality of biological entities when detected using the imaging apparatus, the method of provision being arranged such that said marker is capable of identifying said objects during a first time period, and said marker is less capable of identifying said objects during a second time period; during the first time period, recording a marked-up image in which spatial definitions of said objects are identifiable from said marker; during the second time period, recording a first image of said plurality of biological entities; and generating a spatial definition for an object in said first image using data derived from said marked-up image.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: July 12, 2011
    Assignee: GE Healthcare UK Limited
    Inventors: Nicholas S. Arini, Ian D. Goodyer, Dietrich O. Ruehlmann, Nicholas Thomas
  • Patent number: 7964075
    Abstract: The present invention relates to an electrode bridge or sample application bridge for use in electrophoresis, preferably isoelectric focusing, IEF. More closely, the invention relates to an electrodic bridge or sample loading bridge for preventing denaturant depletion from the IPG (immobilized pH gradient) gel and, optionally, for loading samples onto the IPG gel. The pH of the bridge is adjustable for adoption to positioning at the acid as well as basic end of the IPG strips.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: June 21, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bengt Bjellqvist, Kristina Uhlen
  • Patent number: 7966227
    Abstract: The present invention relates to a configuration system for configuring and ordering a chemical separation system, which configuration system comprises a configuration tool, a database comprising data relating to chemical separation hardware modules and the linkage of said hardware modules. Said configuration system enables a user in real-time to obtain a customized configuration of the chemical separation system. The present invention also relates to a method of selling a customized chemical separation system using said configuration system. The present invention system and method considerably shorten the time required for customizing a chemical separation system.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: June 21, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Mikael Ingvar Johansson, Sven Torbjörn Blank
  • Patent number: 7957911
    Abstract: Methods and apparatus for screening large numbers of chemical compounds and performing a wide variety of fluorescent assays, including live cell assays. The methods utilize a laser linescan confocal microscope with high speed, high resolution and multi-wavelength capabilities and real time data-processing. Imaging may be done at video-rates and with use of ultraviolet illumination.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: June 7, 2011
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Timothy D. Harris, Richard L. Hansen, William Karsh, Neal A. Nicklaus, Jay K. Trautman
  • Patent number: 7953308
    Abstract: A system and method for fiber optic bundle-based illumination for an imaging system is disclosed. According to one embodiment of the present invention, the system includes a fiber optic bundle that comprising a plurality of optical fibers. Each optical fiber receives light from a light source. The system also includes a beam forming element that selects a mode of operation for the imaging system. The system further includes a beam deflecting device that deflects the light on a sample. According to one embodiment of the present invention, the method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through a fiber optic bundle, the fiber optic bundle comprising a plurality of optical fibers; (3) providing a beam forming element based on the selected mode of operation; and (4) deflecting the focused light on a sample.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: May 31, 2011
    Assignee: General Electric Company
    Inventor: Pavel A. Fomitchov
  • Patent number: 7943029
    Abstract: The present invention relates to a method, composition and a kit for isoelectric focusing. More closely, the present invention involves the use of to modified carrier ampholytes which are easy to separate from the proteins/peptides following finished focusing. The modification is that the carrier ampholytes are derivatised with handles interacting with a solid phase/matrix which makes them easy to remove and separate from the peptides after finished focusing. In this way, there is very little or no background from carrier ampholytes in the following MS-spectra.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: May 17, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bengt Bjellqvist, Henrik Neu, Kristina Uhlen
  • Patent number: 7925448
    Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: April 12, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Robert Karlsson
  • Patent number: 7914983
    Abstract: Provided is a novel approach for generating oligonucleotide probes and the use of these probes in gene expression profiling, by hybridization to test oligonucleotides on arrays or beads. This approach involves labeling of the complement oligonucleotide probes using a mixture of dye or hapten labeled-ddNTPs in solution. The labeled oligonucleotide probes are then used to hybridize to the test oligonucleotides on the solid support. Success in hybridization is monitored by associated signal on the solid support. This approach greatly reduces hybridization time, due to the simplification of the probe content. It is especially useful when analyzing a small number of genes, such as a signature set of genes for a disease or condition.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: March 29, 2011
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Chockalingam Palaniappan, Carl W. Fuller, John R. Nelson
  • Patent number: 7905996
    Abstract: The present invention relate to methods and devices for holding a cell and positioning recording electrodes inside it.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: March 15, 2011
    Assignee: GE Healthcare UK Limited
    Inventor: Edward C. Conley
  • Patent number: D639979
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: June 14, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Dan Hermansson, Roger Lundqvist
  • Patent number: D639980
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: June 14, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: John Davis, Stefan Kjell Eriksson