Patents Represented by Attorney Ywe J. Looper

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  • Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin
    Patent number: 7108998
    Abstract: Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from Streptomyces refuineus subsp. thermotolerans including non-ribosomal peptide synthetases (NRPS). The genes and proteins allow direct manipulation of benzodiazepines and related chemical structures via chemical engineering of the enzymes involved in the biosynthesis of anthramycin.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: September 19, 2006
    Assignee: Ecopia Biosciences inc.
    Inventors: Chirs M. Farnet, Alfredo Staffa
  • Gene encoding a nonribosomal peptide synthetase for the production of ramoplanin
    Patent number: 7078185
    Abstract: The present invention relates to an isolated genetic sequence encoding a nonribosomal peptide synthetase (NRPS) protein which directs the biosynthesis of the antibiotic ramoplanin in microorganisms such as Actinoplanes sp. The isolated gene sequence serves as a substrate for bioengineering of antibiotic structures.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: July 18, 2006
    Assignee: Ecopia BioSciences Inc.
    Inventors: Chris M. Farnet, Emmanuel Zazopoulos, Alfredo Staffa