Patents Represented by Attorney Z. Angela Guo

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  • Protein purification using HCIC and ion exchange chromatography
    Patent number: 8129508
    Abstract: The present invention provides methods for purifying proteins. In particular, the methods employ a two-step non-affinity chromatography process without the use of an in-process tangential flow filtration step.
    Type: Grant
    Filed: March 21, 2006
    Date of Patent: March 6, 2012
    Assignee: Medarex, Inc.
    Inventors: Alahari Arunakumari, Gisela Maria Marques Ferreira
  • Protein purification by citrate precipitation
    Patent number: 8063189
    Abstract: The invention provides methods for isolating proteins in purified form from mixtures by precipitation with citrate. The methods are advantageous in that they effectively separate a protein from lower molecular weight contaminants, including fragments or portions of the protein. Such methods are particularly useful for purifying antibodies from mixtures containing antibody proteolytic fragments and unpaired chains.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: November 22, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alahari Arunakumari, Gisela M. Ferreira