Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.
Type:
Application
Filed:
December 23, 2023
Publication date:
April 18, 2024
Applicant:
206 ORTHO, INC.
Inventors:
Jeffrey A. D'Agostino, Andrew J. CARTER, Craig M. Jones, Arthur Watterson
Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.
Type:
Grant
Filed:
December 7, 2020
Date of Patent:
December 26, 2023
Assignee:
206 ORTHO, INC.
Inventors:
Jeffrey A. D'Agostino, Andrew J. Carter, Craig M. Jones, Arthur C. Watterson
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Grant
Filed:
November 1, 2019
Date of Patent:
November 1, 2022
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Arthur Watterson, Joseph P. Lane, Ian D. McRury, Samantha Marchetti, Nikole Seil, Werner Blank, Charles Hegedus
Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.
Type:
Grant
Filed:
July 2, 2018
Date of Patent:
June 7, 2022
Assignee:
206 ORTHO, INC.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Andrew J. Carter, Arthur Watterson, Joseph P. Lane, Ian D. McRury, Samantha Marchetti, Nikole Seil
Abstract: A composite implant comprising a bioabsorbable matrix material, an outer sheath of a textile comprising filaments; and a plurality of flexible reinforcing rods held together by the outer sheath; each of the flexible reinforcing rods have a plurality of filaments, and the filaments of the textile and the flexible reinforcing rods include a degradable or resorbable glass. Preferably, the filaments are present in the composite implant in an amount of 20 volume percent to 95 volume percent, based on the total volume of the composite implant.
Type:
Grant
Filed:
October 18, 2019
Date of Patent:
April 5, 2022
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Andrew J. Carter, Arthur Watterson, Joseph P. Lane
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Grant
Filed:
November 1, 2019
Date of Patent:
December 28, 2021
Assignee:
206 ORTHO, INC.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Arthur Watterson, Werner Blank, Charles Hegedus, Sandip Agarwal, Elizabeth Nelson
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Application
Filed:
May 9, 2019
Publication date:
October 7, 2021
Applicant:
206 Ortho, Inc.
Inventors:
Jeffrey A. D'AGOSTINO, Werner BLANK, Charles HEGEDUS, Sandip AGARWAL, Elizabeth NELSON
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Grant
Filed:
November 13, 2017
Date of Patent:
July 13, 2021
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Werner Blank, Charles Hegedus, Sandip Agarwal, Elizabeth Nelson, Robert S. Whitehouse
Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymetbylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.
Type:
Grant
Filed:
May 17, 2016
Date of Patent:
December 8, 2020
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Andrew J. Carter, Craig M. Jones, Arthur C. Watterson
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
January 7, 2020
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Arthur Watterson, Joseph P. Lane, Ian D. McRury, Samantha Marchetti, Nikole Seil, Werner Blank, Charles Hegedus
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Grant
Filed:
May 8, 2015
Date of Patent:
January 7, 2020
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Arthur Watterson, Werner Blank, Charles Hegedus, Sandip Agarwal, Elizabeth Nelson
Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.
Type:
Grant
Filed:
July 19, 2018
Date of Patent:
December 31, 2019
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Andrew J. Carter, Arthur Watterson, Joseph P. Lane
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Application
Filed:
May 8, 2015
Publication date:
April 25, 2019
Applicant:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Arthur Watterson, Werner Blank, Charles Hegedus, Sandip Agarwal, Elizabeth Nelson
Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.
Type:
Grant
Filed:
April 26, 2016
Date of Patent:
July 24, 2018
Assignee:
206 Ortho, Inc.
Inventors:
Jeffrey A. D'Agostino, Andrew J. Carter, Arthur Watterson, Joseph P. Lane
Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone. A method for treating a bone comprising: selecting at least one reinforcing element to be combined with an injectable matrix material to form a composite implant capable of supporting the bone; positioning the at least one reinforcing element in a cavity in the bone; flowing the injectable matrix material into the cavity wherein the injectable matrix material interfaces with the at least one reinforcing element; and transforming the injectable matrix material from a flowable state to a nonflowable state to establish a static structure that supports the adjacent bone.
Type:
Grant
Filed:
May 23, 2014
Date of Patent:
July 3, 2018
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Andrew J. Carter, Arthur Watterson, Joseph P. Lane, Ian D. McRury, Samantha Marchetti, Nikole Seil
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Type:
Application
Filed:
May 8, 2015
Publication date:
August 24, 2017
Applicant:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Robert S. Whitehouse, Andrew J. Carter, Arthur Watterson, Joseph P. Lane, Ian D. McRury, Samantha Beauregard, Nikole Seil, Werner Blank, Charles Hegedus, Sandip Agarwal
Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.
Type:
Grant
Filed:
February 28, 2013
Date of Patent:
April 26, 2016
Assignee:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Andrew J. Carter, Arthur Watterson, Joseph P. Lane
Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.
Type:
Application
Filed:
February 28, 2014
Publication date:
June 26, 2014
Applicant:
206 ORTHO, Inc.
Inventors:
Jeffrey A. D'Agostino, Andrew J. Carter, Craig M. Jones, Arthur C. Watterson