Abstract: Disclosed is a five-membered heteroaromatic ring structure containing compound, pharmaceutical compositions thereof and applications thereof. The present disclosure provides a five-membered heteroaromatic ring structure containing compound of formula I, pharmaceutical compositions thereof and applications thereof and the five-membered heteroaromatic ring structure containing compound is expected to treat and/or prevent various PARG-related diseases.

Abstract: Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical composition thereof and application thereof. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compounds as represented in Formula I in the present disclosure have good inhibitory effects on cells of various mutations such as KRAS G12C, KRAS G12D, KRAS G12V, KRAS Q61H and other mutations, as well as on KRAS-amplified wild-type cells, and are expected to treat and/or prevent a wide range of diseases associated with Ras.

Abstract: Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical compositions thereof and use thereof. The present disclosure provides a nitrogen-containing heterocyclic compound represented by formula I, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of pharmaceutically acceptable salt thereof, a crystal thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compound represented by formula I is expected to treat and/or prevent various PI3K-meditated diseases.

Abstract: Disclosed is a nitrogen-containing heterocyclic compound, a method for preparing the same and a use of the same. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof, and the nitrogen-containing heterocyclic compound is expected to treat and/or prevent various RAS-related diseases.

Abstract: Disclosed is a five-membered heteroaromatic ring structure containing compound, pharmaceutical compositions thereof and applications thereof. The present disclosure provides a five-membered heteroaromatic ring structure containing compound of formula I, pharmaceutical compositions thereof and applications thereof and the five-membered heteroaromatic ring structure containing compound is expected to treat and/or prevent various PARG-related diseases.