Abstract: Systems and techniques are provided for automatically analyzing and processing domain-specific image artifacts and document images. A process can include obtaining a plurality of document images comprising visual representations of structured text. An OCR-free machine learning model can be trained to automatically extract text data values from different types or classes of document image, based on using a corresponding region of interest (ROI) template corresponding to the structure of the document image type for at least initial rounds of annotations and training. The extracted information included in an inference prediction of the trained OCR-free machine learning model can be reviewed and validated or corrected correspondingly before being written to a database for use by one or more downstream analytical tasks.