Abstract: A method of processing regions of interest (ROI) obtained using computed-aided detection (CAD) along with reference image data to assist in evaluation of disease within an anatomical volume. After obtaining ROIs and reference image data, additional information related to each ROI is automatically computed. Subsets of ROIs are selected for use in visualization. ROIs are then presented to an observer in interactive, linked views, each view presenting optimally certain aspects of the ROIs and mapping ROI inclusion within the subsets to visual parameters.