Patents Assigned to 396419 B.C. Ltd.
  • Stem-loop compositions and methods for inhibiting factor D
    Patent number: 11466276
    Abstract: The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease. In some cases, stem-loop aptamers are provided for the inhibition of Factor D.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: October 11, 2022
    Assignees: 396419 B.C. Ltd., Albert Einstein College of Medicine
    Inventors: Carl Erickson, Christopher P. Rusconi, Kevin G. McLure, Matthew Levy, Arijit Bhowmick
  • Compositions and methods for inhibiting factor D
    Patent number: 11274307
    Abstract: The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: March 15, 2022
    Assignee: 396419 B.C. Ltd.
    Inventors: Carl Erickson, Christopher P. Rusconi, Kevin G. McLure