Abstract: Provided are methods for prognosing a clinical outcome in a subject with a hematological disorder comprising determining a 3D telomeres organization signature of a test sample cell from the subject, wherein the 3D telomeres organization signature of the test sample cell is indicative of the clinical outcome of the subject.
Type:
Grant
Filed:
December 3, 2012
Date of Patent:
May 8, 2018
Assignee:
3D Signatures Holdings Inc.
Inventors:
Sabine Mai, Hans Knecht, Macoura Gadji, Ade Olujohungbe
Abstract: A method of measuring a characteristic optionally a clinical characteristic of a cancer test cell sample comprising: characterizing nuclear organization of DNA of the test cell sample: obtaining DNA image data of the cancer test cell sample nuclei using microscopy, processing the image data using granulometry to obtain one or more data points corresponding to DNA occupied space and/or DNA low space; and quantifying a feature of the DNA occupied space and/or a feature of the DNA low space.
Type:
Grant
Filed:
September 11, 2015
Date of Patent:
October 10, 2017
Assignee:
3D Signatures Holdings Inc.
Inventors:
Sabine Mai, Sjoerd Stallinga, Ian T. Young, Lucas J. van Vliet, Christiaan Righolt