Patents Assigned to 3F Therapeutics, Inc.
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Publication number: 20090326524Abstract: A method of cutting tissue for use as an implantable medical device employs a laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source tissue according to predetermined pattern as designated by the computer. The cutting energy of the laser is selected so that the cut edges of the tissue segments are fused, melted or welded to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the tissue adjacent the edge.Type: ApplicationFiled: August 27, 2009Publication date: December 31, 2009Applicant: 3F Therapeutics, IncInventors: Douglas S. Cali, Keith E. Myers
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Patent number: 7604650Abstract: Methods and assemblies are described for capturing embolic material in a blood vessel or other body cavity during cardiovascular or valve replacement and repair surgery, wherein access is provided through the apical area of the patient's heart. The distal embolic protection assembly generally comprises a sleeve having a lumen, an actuating member having proximal and distal ends, wherein the actuating member is movably disposed within the lumen, and a filter assembly coupled to the distal end of the actuating member. The filter assembly generally comprises a porous bag having an open proximal end, a collapsible and expandable frame that is coupled to the open proximal end of the porous bag, and at least one support spine disposed at least a part of the longitudinal axis of the porous bag. The porous bag is configured such that it permits blood to perfuse freely through while capturing embolic material and other debris.Type: GrantFiled: September 10, 2004Date of Patent: October 20, 2009Assignee: 3F Therapeutics, Inc.Inventor: Bjarne Bergheim
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Patent number: 7594974Abstract: A method of cutting material for use in an implantable medical device employs a plotted laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source material according to a predetermined pattern as designated by the computer. The segments are used in constructing implantable medical devices. The cutting energy of the laser is selected so that the cut edges of the segments are melted to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the segment adjacent the edge.Type: GrantFiled: December 8, 2004Date of Patent: September 29, 2009Assignee: 3F Therapeutics, Inc.Inventors: Douglas S. Cali, Keith E. Myers
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Publication number: 20090188900Abstract: A method of cutting material for use in an implantable medical device employs a plotted laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source material according to predetermined pattern as designated by the computer. The segments are used in constructing implantable medical devices. The cutting energy of the laser is selected so that the cut edges of the segments are melted to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the segment adjacent the edge.Type: ApplicationFiled: February 13, 2009Publication date: July 30, 2009Applicant: 3F Therapeutics, Inc.Inventors: Douglas S. Cali, Keith E. Myers
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Patent number: 7530995Abstract: A method of protecting an upper and a lower body of a patient from high venous pressures comprising: providing an elongate valve stent, wherein the stent comprises a first stent member with a first tissue valve secured to a first support structure being disposed at a first end of the stent and a second stent member with a second tissue valve secured to a second support structure being disposed at an opposite second end of the stent, wherein both support structures are collapsibly expandable, the second end being connected to the first end with at least one elongate connecting member; passing the elongate valve stent through a blood vessel with the first and second support structures in a collapsed position; and securing the first support structure to an inferior vena cava and the second support structure to a superior vena cava with both support structures in an expanded shape.Type: GrantFiled: April 17, 2003Date of Patent: May 12, 2009Assignee: 3F Therapeutics, Inc.Inventors: Rodolfo C. Quijano, Patrick M. McCarthy
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Publication number: 20080249620Abstract: A valve holder assembly having a main valve holder and a detachable secondary valve holder for positioning a heart valve prosthesis and a method of implanting a stentless heart valve prosthesis are disclosed.Type: ApplicationFiled: June 16, 2008Publication date: October 9, 2008Applicant: 3F Therapeutics, Inc.Inventor: Demetrio Bicer
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Patent number: 7410499Abstract: A valve holder assembly having a main valve holder and a detachable secondary valve holder for positioning a heart valve prosthesis.Type: GrantFiled: April 8, 2005Date of Patent: August 12, 2008Assignee: 3F Therapeutics, Inc.Inventor: Demetrio Bicer
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Publication number: 20070270944Abstract: The present invention provides valve prostheses adapted to be initially crimped in a narrow configuration suitable for catheterization through body ducts to a target location and adapted to be deployed by exerting substantially radial forces from within by means of a deployment device to a deployed state in the target location.Type: ApplicationFiled: March 12, 2007Publication date: November 22, 2007Applicant: 3F Therapeutics, Inc.Inventors: Bjarne Bergheim, Keith Myers, Jeff DuMontelle, Christine Nguyen
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Publication number: 20070173932Abstract: An improved prosthetic mitral valve is provided having advantageous hemodynamic performance, nonthrombogenicity, and durability. The valve includes a valve body having an inflow annulus and an outflow annulus. Commissural attachment locations are disposed adjacent the outflow annulus. An anterior leaflet and a posterior leaflet of the valve are shaped differently from one another. The inflow annulus preferably is scalloped so as to have a saddle-shaped periphery having a pair of relatively high portions separated by a pair of relatively low portions. The anterior high portion preferably is vertically higher than the posterior high portion.Type: ApplicationFiled: December 7, 2006Publication date: July 26, 2007Applicant: 3F THERAPEUTICS, INC.Inventors: Douglas Cali, Keith Myers, Brian Biancucci, Jason Artof, Christine Nguyen, Rodolfo Quijano
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Patent number: 7159593Abstract: A method of protecting an upper body and a lower body of a patient from high venous pressures comprising implanting a first stented valve at the superior vena cava and a second stented valve at the inferior vena cava, wherein the first and second valves are configured to permit blood flow towards a right atrium of the patient and prevent blood flow in an opposite direction.Type: GrantFiled: April 17, 2003Date of Patent: January 9, 2007Assignee: 3F Therapeutics, Inc.Inventors: Patrick M. McCarthy, Rodolfo C. Quijano Quijano
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Patent number: 7101396Abstract: Methods and systems for minimally invasive replacement of a valve. The system includes a collapsible valve and anchoring structure, devices and methods for expanding the valve anchoring structure, adhesive means to seal the valve to the surrounding tissue, a catheter-based valve sizing and delivery system, native valve removal means, and a temporary valve and filter assembly to facilitate removal of debris material. The valve assembly comprises a valve and anchoring structure for the valve, dimensioned to fit substantially within the valve sinus.Type: GrantFiled: October 6, 2003Date of Patent: September 5, 2006Assignee: 3F Therapeutics, Inc.Inventors: Jason Artof, Tuoc Tan Nguyen, Keith E. Myers
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Patent number: 7044966Abstract: Methods and systems for minimally invasive replacement of a valve. The system includes a collapsible valve and anchoring structure, devices and methods for expanding the valve anchoring structure, adhesive means to seal the valve to the surrounding tissue, a catheter-based valve sizing and delivery system, native valve removal means, and a temporary valve and filter assembly to facilitate removal of debris material. The valve assembly comprises a valve and anchoring structure for the valve, dimensioned to fit substantially within the valve sinus.Type: GrantFiled: October 6, 2003Date of Patent: May 16, 2006Assignee: 3F Therapeutics, Inc.Inventors: Oleg Svanidze, Keith E. Myers
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Patent number: 7041132Abstract: This invention discloses a percutaneous delivered heart valve and delivery means thereof, wherein the percutaneous delivered heart valve is a twistedly foldable heart valve prosthesis comprising a generally cylindrical support element with a diameter, wherein the support element is twistedly foldable to a smaller diameter, a flexible heart valve with a plurality of valvular leaflets releasably attached to said support element, and a receptacle having a plurality of connecting members secured to the cylindrical support element, wherein the receptacle is releasably matched to an expanding element capable of untwisting the receptacle adapted for un-twisting and unfolding said heart valve.Type: GrantFiled: August 16, 2002Date of Patent: May 9, 2006Assignee: 3F Therapeutics, Inc,Inventors: Rodolfo C. Quijano, Hosheng Tu
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Patent number: 7037333Abstract: A tubular prosthetic semilunar or atrioventricular heart valve is formed by cutting flat, flexible leaflets according to a pattern. The valve is constructed by aligning the side edges of adjacent leaflets so that the leaflet inner faces engage each other, and then suturing the leaflets together with successive stitches along a fold line adjacent the side edges. The stitches are placed successively from a proximal in-flow end of each leaflet toward a distal out-flow end. During operation, when the leaflets open and close, the leaflets fold along the fold line. Distal tabs extend beyond the distal end of each leaflet. The successive stitches terminate proximal of the distal tab portion so that no locked stitches are placed along the distal portion of the fold line. The tab portions of adjacent leaflets are folded over each other and sewn together to form commissural attachment tabs.Type: GrantFiled: January 5, 2004Date of Patent: May 2, 2006Assignee: 3F Therapeutics, Inc.Inventors: Keith Myers, Christine Nguyen
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Patent number: 6979350Abstract: A valve prosthesis is disclosed which is implantable within a vein or other blood vessel of a patient using a minimally-invasive surgical procedure. The prosthesis includes a tubular wire frame which presses radially outward against the inner walls of the blood vessel following implantation to hold the prosthesis in position. Multiple flow-resistive pockets that open and close in response to changes in blood flow direction are attached to the frame to impede the flow of blood in the reverse direction. The prosthesis is implanted using an introducer catheter which holds the prosthesis in a radially-compressed state as the prosthesis is inserted into and positioned within the blood vessel.Type: GrantFiled: July 15, 2003Date of Patent: December 27, 2005Assignee: 3F Therapeutics, Inc.Inventors: Franciscus Laurens Moll, Menno Kalmann
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Patent number: 6974464Abstract: A supportless atrioventricular valve intended for attaching to a circumferential valve ring and papillary muscles of a patient comprising a singular flexible membrane of tissue or synthetic biomaterial, wherein a minimally invasive delivery system is provided through a percutaneous intercostal penetration and a penetration at the cardiac wall into a left atrium of the heart.Type: GrantFiled: May 2, 2002Date of Patent: December 13, 2005Assignee: 3F Therapeutics, Inc.Inventors: Rodolfo C. Quijano, Than Nguyen, Hosheng Tu
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Patent number: 6939359Abstract: This invention discloses a medical catheter and methods for removing a defective valve from a patient endoluminally. The method may comprise inserting a medical catheter endoluminally to a site of the defective valve; deploying a coupling mechanism of said medical catheter to stabilize and immobilize a free edge of at least one valve leaflet; deploying a cutting mechanism of said medical catheter to cut a valve base of said defective valve; and removing said defective valve from the patient.Type: GrantFiled: February 26, 2003Date of Patent: September 6, 2005Assignee: 3F Therapeutics, Inc.Inventors: Hosheng Tu, Rodolfo C. Quijano
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Patent number: 6911043Abstract: A tubular prosthetic semilunar or atrioventricular heart valve is formed by cutting flat, flexible leaflets according to a pattern. The valve is constructed by aligning the side edges of adjacent leaflets so that the leaflet inner faces engage each other, and then suturing the leaflets together with successive stitches along a fold line adjacent the side edges. The stitches are placed successively from a proximal in-flow end of each leaflet toward a distal out-flow end. During operation, when the leaflets open and close, the leaflets fold along the fold line. Distal tabs extend beyond the distal end of each leaflet. The successive stitches terminate proximal of the distal tab portion so that no locked stitches are placed along the distal portion of the fold line. The tab portions of adjacent leaflets are folded over each other and sewn together to form commissural attachment tabs.Type: GrantFiled: January 5, 2004Date of Patent: June 28, 2005Assignee: 3F Therapeutics, Inc.Inventors: Keith Myers, Christine Nguyen
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Patent number: 6875231Abstract: A percutaneously deliverable heart valve prosthesis and method of delivery, wherein the prosthesis is anchored to a valvular annulus of a patient and used to replace the patient's diseased valve. The prosthesis is supported by a rigid frame that is generally fixed, but capable of being modified between a first collapsed position and a second expanded position. In its first collapsed position, the prosthesis has sufficient flexibility and is of such a low profile that it allows for easy percutaneously delivery. Upon proper delivery, the prosthesis is anchored and modifiable to a generally permanent expanded position sufficiently rigid to resist the strong recoil force exerted by a distorted stenosed valve orifice displaced by the prosthesis.Type: GrantFiled: September 11, 2002Date of Patent: April 5, 2005Assignee: 3F Therapeutics, Inc.Inventors: James Peter Anduiza, Rodolfo C. Quijano, Hosheng Tu
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Patent number: 6872226Abstract: A method of cutting material for use in an implantable medical device employs a plotted laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source material according to a predetermined pattern as designated by the computer. The segments are used in constructing implantable medical devices. The cutting energy of the laser is selected so that the cut edges of the segments are melted to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the segment adjacent the edge.Type: GrantFiled: July 26, 2002Date of Patent: March 29, 2005Assignee: 3F Therapeutics, Inc.Inventors: Douglas S. Cali, Keith E. Myers