Abstract: Methods of identifying a compound that selectively modulates at least one TLR-mediated cellular activity are disclosed. Generally, the methods include identifying a compound as a compound that selectively modulates at least one TLR-mediated cellular activity if the compound modulates one TLR-mediated cellular activity to a different extent than it modulates a second TLR-mediated cellular activity. Compounds so identified and pharmaceutical compositions including such compounds are also disclosed. Methods of selectively modulating immune cells and methods of treating certain conditions are also provided. Such methods include administering to cells or a subject a compound that selectively modulates a TLR-mediated cellular activity.

Abstract: An apparatus and method provide for automated converting of a web of a thin patterned catalyst-coated membrane to separate membrane sheets for fuel cell assembly. The membrane typically has a thickness of about one thousandth of an inch. Automated web converting involves transporting, with use of a movable vacuum, an end portion of the membrane web from a first location to a second location. With use of respective first and second vacuums at the first and second locations, and after removal of the movable vacuum, the end portion of the membrane web is releasably secured at the first and second locations. The membrane web is cut within a gap defined between a single catalyst pattern of the membrane web end portion and an adjacent catalyst pattern to produce a membrane sheet. The membrane sheet is precisely positioned to a desired orientation to facilitate subsequent processing of the membrane sheet.

Abstract: A bearing assembly is disclosed, which comprises at least two slidable fasteners interengaged with at least two bearing pieces such that the slidable fasteners have substantially unrestricted biaxial motion relative to one another. The bearing pieces are comprised of self-closable fastener film comprising a base sheet and a multiplicity of ribs projecting from the base sheet, wherein the flat side of the first bearing piece is attached to the flat side of the second bearing piece such that the ribs of the first bearing piece are not parallel relative to the ribs of the second bearing piece.

Abstract: In an aspect of the invention, a fluoropolymer dispersion, preferably a PTFE dispersion, is provided that comprises fluoropolymer particles having an average particle size of 10 to 400 nm dispersed in water whereby the dispersion has an amount of solids between 35 and 70% by weight. The dispersion is free of fluorinated surfactant having a molecular weight of less than 1000 g/mol (hereinafter called low molecular weight fluorinated surfactant) or contains the low molecular weight fluorinated surfactant in an amount of not more than 0.05% by weight based on the total weight solids of the dispersion. The dispersion further comprises a non-ionic non-fluorinated surfactant or mixture of non-ionic non-fluorinated surfactants and one or more non-fluorinated anionic surfactants. Through the use of a non-fluorinated anionic surfactant, a dispersion is obtained that has a low viscosity at room temperature (20° C.).

Abstract: An aqueous coating composition is provided comprising carbon particles, one or more highly fluorinated polymers and one or more amine oxide surfactants, typically an amine oxide surfactant according to formula I: 1

Abstract: A mill roll analysis system is described that includes a user interface module, a structural analysis engine, and an analysis control script. The user interface module receives mill roll design data from a remote user via a computer network. The analysis control script automatically directs the structural analysis engine to define and evaluate an appropriate analytical model for the mill roll design based on the mill roll design data. The mill roll analysis system presents an intuitive web-based interface for capturing the mill roll design data, and may present predefined mill roll applications and mill roll types for selection for the user. As a result, the remote user need not be familiar with the underlying analytical modeling techniques, which may be highly-complex by nature. Consequently, a user may utilize the system to evaluate and improve mill roll design in order to achieve increased product performance.

Abstract: A composite article having large scale predictable dimensional stability comprises a metal foil backing having adhered thereto a layer of cured polymer having an exposed surface bearing a three-dimensional microstructure of precisely shaped and located functional discontinuities. The article is made by depositing a layer of a radiation curable composition onto a metal foil backing, contacting a master with a pattern capable of imparting a three-dimensional microstructure of precisely shaped and located functional discontinuities into the layer of radiation curable composition, while the layer of radiation curable composition is in contact with the master, exposing the curable composition to radiation to cure the composition, and separating the cured polymer layer on the metal foil backing from the surface of the master. Either the metal foil backing or the master may be radiation transmissive.

Abstract: A black matrix can be formed by thermal transfer on a receptor substrate for use, for example, in a display application. This black matrix can be used, for example, as a color filter black matrix or a TFT (thin film transistor) black matrix to provide contrast and/or to separate adjacent electrically-conducting components.

Abstract: Initiators for nitroxide-mediated radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers.

Abstract: A water- and oil-repellent, antistatic composition comprises (a) at least one nonpolymeric ionic salt consisting of (i) at least one cation selected from the group consisting of monovalent metal cations, divalent metal cations, and organic onium cations, and (ii) at least one weakly coordinating anion, the conjugate acid of the anion having an acidity greater than or equal to that of a hydrocarbon sulfonic acid, and with the proviso that the anion is organic or fluoroorganic when the cation is a metal; (b) at least one fluorochemical repellency-imparting additive or repellent; and (c) at least one insulating material. The composition exhibits good antistatic and repellency characteristics.

Abstract: Initiators for nitroxide-mediated radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers.

Abstract: A polarization transformer can be constructed using a continuously adjustable polarization transforming device and a limited-range adjustable polarization transforming device. In general, the response time of the limited-range adjustable polarization transforming device is faster than that of the continuously adjustable polarization transforming device. When the two devices are properly controlled using error signals derived from a transformed optical signal, the polarization state of the optical signal can be adjusted with sufficient speed and without the loss of control associated with reset cycles.

Abstract: A coated laminate having an ionic surface including a shrinkable polymeric film, an ionic coating and, optionally, a hydrogel is disclosed. A method for transferring sample molecules from a matrix to a coated laminate having an ionic surface also is disclosed.

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract: A filament coating apparatus comprising a frame for releasably securing a filament, and a carriage mounted on the frame to oscillate between a first position and a second position. There is a first filament holding fixture mounted on the carriage and a second filament holding fixture also mounted on the carriage in axial alignment with the first filament holding fixture to secure a measured filament portion, preferably of an optical fiber, including a bare portion thereof, located inside a first boundary and a second boundary, between the first filament holding fixture and the second filament holding fixture. At least one spray head is attached to the frame at the first position with at least one radiation source attached to the frame at the second position.

Abstract: Methods and apparatuses are provided for the manufacture of coextruded polymeric multilayer optical films. The multilayer optical films have an ordered arrangement of layers of two or more materials having particular layer thicknesses and a prescribed layer thickness gradient throughout the multilayer optical stack. The methods and apparatuses described allow improved control over individual layer thicknesses, layer thickness gradients, indices of refraction, interlayer adhesion, and surface characteristics of the optical films. The methods and apparatuses described are useful for making interference polarizers, mirrors, and colored films that are optically effective over diverse portions of the ultraviolet, visible, and infrared spectra.

Abstract: An illumination system for a reflective display is particularly useful for microdisplays that use reflective displays. The light source and the reflective image display unit are mounted in a coplanar manner, thus permitting the light source and the display unit to be mounted on a single board, or even on a single substrate. The display unit may include a first light source directing light generally along a first axis and a reflective image display unit disposed with an optical axis substantially parallel to the first axis. A reflective polarizing film is disposed to direct light from the first light source to the reflective image light display unit.

Abstract: A combinatorial array comprises fluid-impervious, sealed or sealable, flexible, self-supported pouches, each pouch comprising therein one or more members of a library of materials. A method for producing the members of the library is also disclosed. The method can utilize an automated process for introducing components into the pouches. Analysis of products can be by destructive or non-destructive methods.

Abstract: A wall repair compound useful for filling and repairing cracks, holes, and other imperfections in a wall surface includes a conventional filler material, a conventional binder material, and a dust reducing additive which reduces the quantity of airborne dust particles generated when sanding the hardened joint compound. Airborne dust reducing additives include oils, surfactants, solvents, waxes, and other petroleum derivatives. The additive can be added to conventional ready-mixed joint compounds and to setting type joint compounds. A method of reducing the quantity of airborne dust generated when sanding a fully hardened joint compound includes mixing a sufficient quantity of the dust reducing additive with the joint compound prior to when the joint compound has been applied to the wall.