Patents Assigned to 4-Antibody AG
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Patent number: 9346874Abstract: The invention relates to binding members, especially antibody molecules, which may neutralize the biological effects of human cytomegalovirus (hCMV). The binding members may be useful for the treatment and prophylaxis of hCMV infection.Type: GrantFiled: June 22, 2012Date of Patent: May 24, 2016Assignee: 4-Antibody AGInventors: Ulf Grawunder, Michael Mach, Luis Martin-Parras, Sonja Potzsch, Nadja Spindler, Heinrich Sticht, Anna-Katharina Wiegers, Thomas Winkler
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Publication number: 20140227786Abstract: The present invention relates to methods of host cell transduction utilising ecotropic retroviral vector particles. The retroviral vector particle may comprise an envelope of Friend murine leukaemia virus, in particular the envelope encoded by molecular clone PVC-211 and the host cell may be engineered to recombinantly express the Rec1 receptor. The retroviral vector particles and methods of the invention can be used to introduce expressible polynucleotide sequences of interest into host cells with high efficiency. This results in protein production methods with higher yield (mg/L) and a reduction in manufacturing costs that could be used in a range of applications including for example, the production of therapeutic proteins, vaccines and antibodies.Type: ApplicationFiled: January 27, 2014Publication date: August 14, 2014Applicant: 4-Antibody AGInventor: Jörn Stitz
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Patent number: 8748353Abstract: The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.Type: GrantFiled: March 4, 2009Date of Patent: June 10, 2014Assignee: 4-Antibody AGInventors: Ulf Grawunder, Jorn Stitz
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Patent number: 8716194Abstract: The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.Type: GrantFiled: September 29, 2011Date of Patent: May 6, 2014Assignee: 4-Antibody AGInventors: Ulf Grawunder, Jorn Stitz
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Patent number: 8663989Abstract: The present invention relates to methods of host cell transduction utilizing ecotropic retroviral vector particles. The retroviral vector particle may comprise an envelope of Friend murine leukaemia virus, in particular the envelope encoded by molecular clone PVC-211 and the host cell may be engineered to recombinantly express the Reel receptor. The retroviral vector particles and methods of the invention can be used to introduce expressible polynucleotide sequences of interest into host cells with high efficiency. This results in protein production methods with higher yield (mg/L) and a reduction in manufacturing costs that could be used in a range of applications including for example, the production of therapeutic proteins, vaccines and antibodies.Type: GrantFiled: November 22, 2010Date of Patent: March 4, 2014Assignee: 4-Antibody AGInventor: Jörn Stitz
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Publication number: 20130089559Abstract: The invention relates to binding members, especially antibody molecules, which may neutralise the biological effects of human cytomegalovirus (hCMV). The binding members may be useful for the treatment and prophylaxis of hCMV infection.Type: ApplicationFiled: June 22, 2012Publication date: April 11, 2013Applicant: 4-Antibody AGInventors: Ulf Grawunder, Michael Mach, Luis Martin-Parras, Sonja Pötzsch, Nadja Spindler, Heinrich Sticht, Anna-Katharina Wiegers, Thomas Winkler
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Publication number: 20120021491Abstract: The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.Type: ApplicationFiled: September 29, 2011Publication date: January 26, 2012Applicant: 4-ANTIBODY AGInventors: Ulf GRAWUNDER, Jorn STITZ
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Publication number: 20110059056Abstract: The present invention generally relates to the fields of genetic engineering and antibody production. In particular, it relates to the generation of genetically modified vertebrate precursor lymphocytes that have the potential to differentiate into more mature lymphoid lineage cells, and to the use thereof for the production of any heterologous antibody or binding protein.Type: ApplicationFiled: December 18, 2009Publication date: March 10, 2011Applicant: 4-ANTIBODY AGInventors: ULF GRAWUNDER, GEORG FRIEDRICH MELCHERS
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Patent number: 7741077Abstract: The present invention generally relates to the fields of genetic engineering and antibody production. In particular, it relates to the generation of genetically modified vertebrate precursor lymphocytes that have the potential to differentiate into more mature lymphoid lineage cells, and to the use thereof for the production of any heterologous antibody or binding protein.Type: GrantFiled: December 22, 2001Date of Patent: June 22, 2010Assignee: 4-Antibody AGInventors: Ulf Grawunder, Georg Friedrich Melchers
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Publication number: 20090226922Abstract: The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.Type: ApplicationFiled: March 4, 2009Publication date: September 10, 2009Applicant: 4-Antibody AGInventors: Ulf GRAWUNDER, Jorn STITZ