Patents Assigned to 4D Pharma Research Limited
  • Compositions comprising bacterial strains
    Patent number: 11660319
    Abstract: The invention provides compositions comprising commensal bacterial strains and organic acids and the uses thereof in the treatment of diseases.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: May 30, 2023
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Elisabeth Mulder, Anna Ettorre, Suaad Ahmed, Parthena Fotiadou, Samantha Yuille, Joseph Roby Iringan Urcia, Helene Savignac
  • Compositions comprising bacterial strains
    Patent number: 11504405
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing lung injury or lung disease.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: November 22, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Mulder, Alexander Stevenson, Helene Savignac
  • Compositions comprising bacterial strains
    Patent number: 11446336
    Abstract: The invention provides a composition comprising a bacterial strain of the genus Parabacteroides, for use in a method of treating or preventing cancer in a subject; wherein the cancer comprises oncogenic ERK signalling.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: September 20, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Elisabeth Mulder, Anna Ettorre, Suaad Ahmed, Parthena Fotiadou
  • Compositions comprising bacterial strains
    Patent number: 11433106
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: September 6, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: George Grant, Angela Margaret Patterson, Imke Mulder, Seanin McCluskey, Emma Raftis
  • Compositions comprising bacterial strains
    Patent number: 11419931
    Abstract: The invention provides compositions comprising bacterial strains for stimulating the immune system and treating and preventing diseases.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: August 23, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Domenico Panzica, Amy Beth Holt, Suaad Ahmed, Anna Ettorre, Imke Elisabeth Mulder, Philip Cowie, Emma Raftis, Emma Elizabeth Clare Hennessy, Delphine Louise Claudette Laute-Caly, Aurélie Pascale Patricia Couturier-Maillard, Margaret Inkster Delday, Marsilio Adriani, Maria Christofi
  • Compositions comprising bacterial strains
    Patent number: 11419902
    Abstract: The invention provides a composition comprising a bacterial strain of the genus Megasphaera, for use in stimulating the immune system in subject.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: August 23, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Elisabeth Mulder, Parthena Fotiadou, Amy Beth Holt, Suaad Ahmed, Anna Ettorre, Samantha Yuille, Ted Dinan, John Cryan
  • Polypeptide and immune modulation
    Patent number: 11414463
    Abstract: The present invention relates to Roseburia flagellin, and/or a polynucleotide sequence encoding said Roseburia flagellin, and/or a vector comprising said polynucleotide sequence, and/or a host cell, including bacteria, comprising said vector, and/or a host cell, including bacteria, comprising said polynucleotide sequence, for use in modulating the inflammation of a tissue or an organ in a subject.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: August 16, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Denise Kelly, Angela Patterson, Edouard Monnais, Imke Mulder
  • Compositions comprising bacterial strains
    Patent number: 11389493
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: July 19, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: George Grant, Angela Margaret Patterson, Imke Mulder, Seanin McCluskey, Emma Raftis
  • Compositions comprising bacterial strains
    Patent number: 11382936
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing autoimmune and inflammatory disorders of the central nervous system.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: July 12, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Helene Savignac, Imke Elisabeth Mulder, Alexander James Stevenson
  • Compositions comprising bacterial strains
    Patent number: 11376284
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing central nervous system disorders and conditions.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: July 5, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Helene Savignac, Imke Elisabeth Mulder, Alexander James Stevenson, Ted Dinan, John Cryan
  • Compositions comprising bacterial strains
    Patent number: 11331352
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: May 17, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: George Grant, Angela Margaret Patterson, Imke Mulder, Seanin McCluskey, Emma Raftis
  • Compositions comprising bacterial strains
    Patent number: 11273185
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: March 15, 2022
    Assignee: 4D Pharma Research Limited
    Inventor: Alex Stevenson
  • Bacterium for use as a probiotic for nutritional and medical applications
    Patent number: 11266698
    Abstract: A first aspect of the invention relates to the bacterial species Roseburia hominis for use in: regulating the immune system of a subject treating an immune disorder; treating an intestinal disorder; improving intestinal microbiota; regulating the innate immune system of a subject; regulating the adaptive immune system of a subject; regulating appetite in a subject; promoting Tregs and immune tolerance; promoting gut health in a subject; and/or maintaining immune homeostasis in a subject. Further aspects of the invention relate to compositions comprising Roseburia hominis.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: March 8, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Denise Kelly, Imke Mulder
  • Compositions comprising bacterial strains
    Patent number: 11123378
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing brain injury.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: September 21, 2021
    Assignee: 4D Pharma Research Limited
    Inventors: Helene Savignac, Imke Elisabeth Mulder, Alexander James Stevenson
  • Compositions comprising bacterial strains
    Patent number: 11123379
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing a neurodegenerative disorder.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: September 21, 2021
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Elisabeth Mulder, Anna Ettorre, Suaad Ahmed, Parthena Fotiadou, Samantha Yuille, Helene Savignac
  • Compositions comprising bacterial strains
    Patent number: 11058732
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing cancer.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: July 13, 2021
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Elisabeth Mulder, Amy Beth Holt, Domenico Panzica, Seanin Marie McCluskey
  • Compositions comprising bacterial strains
    Patent number: 11040075
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: June 22, 2021
    Assignee: 4D Pharma Research Limited
    Inventors: George Grant, Angela Margaret Patterson, Imke Mulder, Seanin McCluskey, Emma Raftis
  • Lactic acid bacterial strains
    Patent number: 11013773
    Abstract: A first aspect of the invention relates to a porcine lactic acid bacterial strain, wherein said bacterial strain is characterised by one or more of the following characteristics: (i) the ability to exhibit antimicrobial activity against E. coli; (ii) the ability to exhibit antimicrobial activity against S. enteritidis; (iii) the ability to suppress inflammation in IPEC cells induced by 12-0-tetradecaboylphorbol-13-acetate (PMA); (iv) the ability to block the attachment or invasion of IPEC cells by S. enteritidis; (v) the ability to block the attachment or invasion of IPEC cells by E. coli; (vi) the absence of antibiotic resistance to one or more antibiotics selected from the following: ampicillin; cefotaxime; chloramphenicol; erythromycin; gentamicin; tetracycline; vancomycin; metronizadole; nalidixic acid; and kanamycin; and (vii) the ability to exhibit heat stability when subjected to three cycles of heating, each cycle comprising heating at a temperature of 70° C. for a period of 15 minutes.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: May 25, 2021
    Assignee: 4D Pharma Research Limited
    Inventor: Denise Kelly
  • Compositions comprising a bacterial strain of the genus and uses thereof
    Patent number: 11007233
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing neurodegenerative disorders.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: May 18, 2021
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Elisabeth Mulder, Samantha Yuille, Anna Ettorre, Suaad Ahmed, Parthena Fotiadou, Joseph Roby Iringan Urcia, Helene Savignac
  • Compositions comprising bacterial strain
    Patent number: 10987387
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing cancer.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: April 27, 2021
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Elisabeth Mulder, Emma Raftis, Delphine Louise Claudette Caly, Emma Elizabeth Clare Hennessy