Abstract: Device for selective biological synthesis of a bone tissue including a screw for the stabilization of a fracture or of a porotic bone tissue, wherein said screw is arranged along an axis (X), substantially longitudinal with respect to said screw, and it is constituted by an extended body, from a first end or tip and from a second end or head, wherein at least said extended body and said second end or head include a longitudinal channel, wherein said extended body has at least one hole or slot, wherein said device includes a pin inserted into the longitudinal channel and provided with means for releasable connection with said screw, for reinforcing the device and for the releasable closure thereof.