Patents Assigned to 4SC AG
  • Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
    Publication number: 20040192758
    Abstract: The present invention relates to compounds of the general formula (II) and salts and physiologically functional derivatives thereof, 1
    Type: Application
    Filed: December 17, 2003
    Publication date: September 30, 2004
    Applicant: 4SC AG
    Inventors: Johann Leban, Stefan Tasler
  • Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
    Publication number: 20040176458
    Abstract: The present invention relates to compounds of the general formula (I) and salt and physiologically functional derivatives thereof, 1
    Type: Application
    Filed: December 17, 2003
    Publication date: September 9, 2004
    Applicant: 4 SC AG
    Inventors: Johann Leban, Martin Kralik
  • Method of identifying candidate molecules
    Patent number: 6727100
    Abstract: A method of identifying candidate molecules expected to be biologically active comprises the following steps: Creating a set consisting of different molecules; to each of said molecules of said set, assigning a descriptor representing a predetermined number of molecular properties; mapping said set of molecules onto points of a two-dimensional grid with regard to a predetermined similarity relation of the respective assigned descriptors such that the grid distance between grid points of two molecules is a measure for the similarity of said two molecule descriptors; forming a three-dimensional surface over said grid of molecules, said surface representing the distribution of biological activity of the molecules on the grid approximatively according to a predetermined quality criterion; selecting from said three-dimensional surface candidate molecules satisfying a predetermined criterion with respect to their biological activity.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: April 27, 2004
    Assignee: 4SC AG
    Inventors: Daniel Vitt, Stefan Busemann, Ulrich Dauer
  • Modulation of pathogenicity
    Publication number: 20040063765
    Abstract: The present invention relates to the use of compounds of the general Formula (I): 1
    Type: Application
    Filed: May 6, 2003
    Publication date: April 1, 2004
    Applicant: 4 SC AG
    Inventors: Aldo Ammendola, Katharina Aulinger-Fuchs, Astrid Gotschlich, Bernd Kramer, Martin Lang, Wael Saeb, Udo Sinks, Andreas Wuzik
  • Novel potassium channels modulators
    Publication number: 20040009973
    Abstract: The invention relates to compounds having the Formula (I) 1
    Type: Application
    Filed: March 11, 2003
    Publication date: January 15, 2004
    Applicant: 4SC AG
    Inventors: Heiko Rauer, Gabriel Garcia, Bernd Kramer, Juergen Kraus, Claudia Klemenz, Wael Saeb
  • Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
    Publication number: 20030203951
    Abstract: The present invention relates to novel compounds that can be used as antiinflammatory, immunomodulatory and antiproliferatory agents. In particular the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehydrogenase (DHODH).
    Type: Application
    Filed: July 9, 2002
    Publication date: October 30, 2003
    Applicant: 4SC AG
    Inventors: Johan Leban, Bernd Kramer, Wael Saeb, Gabriel Garcia
  • Novel modulators of potassium channels
    Publication number: 20030203959
    Abstract: The invention relates to the use of a compound of the Formula (I) 1
    Type: Application
    Filed: March 3, 2003
    Publication date: October 30, 2003
    Applicant: 4SC AG
    Inventors: Heiko Rauer, Wael Saeb, Gabriel Garcia, Bernd Kramer, Juergen Kraus, Claudia Klemenz