Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.
Type:
Grant
Filed:
January 27, 2012
Date of Patent:
November 26, 2013
Assignee:
4SC Discovery GmbH
Inventors:
Johann Leban, Stefan Tasler, Roland Baumgartner, Wael Saeb, Carine Chevrier
Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.
Type:
Grant
Filed:
January 27, 2012
Date of Patent:
January 15, 2013
Assignee:
4SC Discovery GmbH
Inventors:
Johann Leban, Stefan Tasler, Wael Saeb, Carine Chevrier
Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.
Type:
Application
Filed:
January 27, 2012
Publication date:
August 2, 2012
Applicant:
4SC Discovery GmbH
Inventors:
Johann LEBAN, Stefan TASLER, Roland BAUMGARTNER, Wael SAEB, Carine CHEVRIER
Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.
Type:
Application
Filed:
January 27, 2012
Publication date:
August 2, 2012
Applicant:
4SC Discovery GmbH
Inventors:
Johann LEBAN, Stefan TASLER, Wael SAEB, Carine CHEVRIER
Abstract: The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.
Type:
Grant
Filed:
July 16, 2007
Date of Patent:
July 24, 2012
Assignee:
4SC Discovery GmbH
Inventors:
Alexander B. Maurer, Sascha Hoevelmann, Elke Martin, Bernd Hentsch, Michael Gassen, Juergen Kraus, Rolf Krauss, Adam-Spencer Vincek