Patents Assigned to 501 Elan Corporation PLC.
  • Patent number: 4826688
    Abstract: A controlled absorption quinidine formulation for oral administration comprises a pellet having a core of quinidine or a pharmaceutically acceptable salt thereof in association with an organic acid and optionally other excipients, and an outer membrane which permits release of quinidine in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured in a Basket Assembly according to U.S. Pharmacopoeia XXI at 37.degree. C. and 75 r.p.m. is not more than 15% after one hour of measurement. Not more than 50% of the total quinidine is release after a total of 4 hours of measurement, not more than 80% is released after a total of 8 hours of measurement and not less than 90% release is achieved after a total of 24 hours.
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: May 2, 1989
    Assignee: 501 Elan Corporation PLC.
    Inventors: Donald E. Panoz, Edward J. Geoghegan