Patents Assigned to 501 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute
  • Method for purification of HBs antigen
    Patent number: 4612283
    Abstract: A method for purification of HBs antigen, which comprises treating an HBs tigen-containing material with an acid, optionally subjecting to salting out with ammonium sulfate, and subjecting the material to a chromatography with hydroxyapatite, by which a highly purified HBs antigen suitable for the preparation of HBV vaccine or diagnostic agent can be obtained in an industrial scale. This method is particularly useful for the purification of HBs antigen-containing material produced by recombinants obtained by DNA recombination technique.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: September 16, 1986
    Assignee: 501 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute
    Inventors: Keishin Sugahara, Chikateru Nozaki, Fukusaburo Hamada, Fumio Miake, Nobuya Ohtomo