Patents Assigned to 501 Regents of the University of California
  • Macrocyclic bifunctional chelating agents
    Patent number: 4678667
    Abstract: A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.
    Type: Grant
    Filed: July 2, 1985
    Date of Patent: July 7, 1987
    Assignee: 501 Regents of the University of California
    Inventors: Claude F. Meares, Sally J. DeNardo, William C. Cole, Min K. Mol