Abstract: A medication compliance package includes an outer carrier of card defining a rear panel into which the pockets of a blister sheet are attached and covered by a foil layer. A front panel folds over the rear panel to cover its front face and the pockets. The front panel has a slot shaped opening along the mutual side edge with the rear panel to allow fingers of the hand of the user to extend through the opening, with the front and rear panels in the open position, from the rear face of the front panel to reach around the mutual side edge to the rear face of the rear panel. This simplifies the act of popping the medications out of the blister since the fingers engage the rear of the rear panel and the thumb can be used to apply pressure to the pockets.