Abstract: Systems and methods are provided herein for improving connections between a heart pump such a left ventricular assist device (LVAD) and the heart and/or tubing such as a graft tube. An apical connector including a cylindrical housing and a ring support connected to the housing is described. The apical connector may include a sewing ring to be connected to the patient's heart and a spring positioned within the cylindrical housing to engage a portion of the pump and secure the apical connector to the pump. Alternatively, an apical connector may include an upper and lower housing with locks positioned in channels between the housings and may include a handle and a ring to cause the locks to engage a portion of the pump. A quick connect assembly is also described for efficiently connecting a graft tube to an outlet of a heart pump using a flange with through-holes and protrusions.

Abstract: Object of the invention is a laser machine and/or a measuring machine adapted for mounting at least one optical device and for rotating it at a workpiece to be processed and/or measured, said turret (10) comprising: —at least one turret body supported by the machine; —at least one rotating drum (120) supported by said turret body and supporting at least two devices chosen from optical, gripping, processing, measuring or vision devices; —a laser scanner mounted, in whole or in part, inside the rotating drum of the above-mentioned turret; —said laser scanner being able to use a laser beam, the above-mentioned laser beam having a reflection axis and being generated by a laser generator external to the above-mentioned turrent (10); wherein—the rotating drug (120) is mounted rotating around said turrent body so as to rotate to bring each device alternatively in alignment with or at the axis of reflection of the laser beam coming from the laser scanner.

Abstract: An aerosol-generating article includes a rod of aerosol-generating substrate, a mouthpiece including a plug of filtration material, a wrapper, and a tobacco-containing layer including tobacco and an aerosol-forming agent, wherein the rod is wrapped by the wrapper and by the tobacco-containing layer, and the tobacco-containing layer is positioned in contact with a surface of the wrapper. A method for producing an aerosol-generating article includes preparing a tobacco-containing slurry, depositing the slurry onto a first sheet to form a sheet coated with a tobacco-containing layer, attaching a paper sheet to the first sheet to form a wrapper before or after depositing the slurry onto the first sheet so that the paper sheet and the tobacco-containing layer are on opposing sides of the first sheet, and subsequently wrapping a rod of aerosol-generating substrate with the wrapper including the first sheet, so that the tobacco-containing layer is facing the rod.

Abstract: A method for processing a cardboard (12) with a laser beam (14) is provided, wherein the laser beam (14) is moved over the cardboard (12) along a desired folding line (24) such that an upper layer of the cardboard (12) is ablated without cutting through the cardboard (12), wherein the laser beam (14) is adjusted such that the laser beam (14) is focused below the cardboard (12). Further, a device (10) for carrying out a method for processing a cardboard (12) with a laser beam (14) is provided.

Abstract: This invention relates to a liquid product in the form of an oil in water or a water in oil emulsion stabilized by a cyclodextrin, methods for obtaining the emulsions, consumer products, and uses thereof.

Abstract: A heater for heating a consumable including a solid aerosol generating substrate includes a base; and a heating element attached to a support surface of the base, wherein the heating element includes a moulding surface configured to deform and heat the aerosol generating substrate. An aerosol generation device includes a substrate storage chamber configured to receive a consumable including a solid aerosol generating substrate, the substrate storage chamber including the aforementioned heater arranged on a surface of the substrate storage chamber with the support surface facing into the substrate storage chamber.

Abstract: The present invention is directed to nucleic acids suitable for use in treatment or prophylaxis of an infection with a coronavirus, such as a Coronavirus SARS-CoV-2 variant, or a disorder related to such an infection, such as COVID-19. The present invention is also directed to compositions, and vaccines. The compositions and vaccines comprise at least one of said nucleic acid sequences, and nucleic acid sequences in association with a lipid nanoparticle (LNP). The invention is also directed to first and second medical uses of the nucleic acids, the composition, the vaccine, and the kit, and to methods of treating or preventing a coronavirus infection, such as a Coronavirus infection from a SARS-CoV-2 variant.

Abstract: The present invention is directed to a nucleic acid suitable for use in treatment or prophylaxis of an infection with a coronavirus, preferably with a Coronavirus SARS-CoV-2, or a disorder related to such an infection, preferably COVID-19. The present invention is also directed to compositions, polypeptides, and vaccines. The compositions and vaccines preferably comprise at least one of said nucleic acid sequences, preferably nucleic acid sequences in association a lipid nanoparticle (LNP). The invention is also directed to first and second medical uses of the nucleic acid, the composition, the polypeptide, the combination, the vaccine, and the kit, and to methods of treating or preventing a coronavirus infection, preferably a Coronavirus infection.

Abstract: A decorative, wearable system includes at least one decorative element mechanically and moveably suspended in a liquid by mechanical fixation elements. The liquid shares a substantially similar refraction index as at least one of mechanical fixation elements.

Abstract: A cutting tool for the vertical incision of tendons comprising a shaft extending along a longitudinal axis, having a distal end and a proximal end, and a cutting head, located close to said distal end, having a plurality of blades. The cutting head lies on a plane parallel to the longitudinal axis of the shaft and is connected to the latter by a coupling inclined with respect to the longitudinal axis by an angle from 10° to 20°, preferably of 15°.

Abstract: A storage basket for hanging on the peripheral edge of an above-ground pool is disclosed including a storage basket including hanging brackets, the hanging brackets include spacers and snap-in openings, the spacers include springs, and the spacers are detachably coupled at their upper end to one of the snap-in openings.

Abstract: Some systems and methods for treating heart tissue may include instruments for intermittently occluding the coronary sinus using a coronary sinus occlusion catheter device. In some embodiments, the coronary sinus occlusion catheter can be used before or during a coronary intervention procedure in which a blockage in a heart is repaired or removed.

Abstract: A computer-implemented method for checking the correct alignment of a hip prosthesis, includes: detecting a 3D model of the pelvic bone of a patient in a preoperative phase, detecting at least one 2D image of the pelvic bone in post-implant situation, selecting an image of the 3D model according to a first inclination thereof and detecting a reference element on said selected image of the 3D model, identifying a plurality of reference points on the 2D image, superimposing the 2D image on said selected image of the 3D model, checking the correct superimposition and correspondence of the reference points of the 2D image with the reference element with said image of the 3D model, and detecting possible differences in the positioning of the pelvic bone in post-implant configuration with respect to the preoperative situation.

Abstract: Disclosed are sweetened consumables and methods of forming said sweetened consumables that comprise certain sweeteners and a compound of formula (1), wherein R1 is selected from the group consisting of OH and OCH3, and R2 is selected from the group consisting of H and OH, R1 and R2 comprise at least one OH group, and when R1 is OH then R2 is H (trilobatin), and when R1 is OCH3 then R2 is OH (HDG), in a concentration near its sweetness detection threshold. The sweeteners include sucrose, fructose, glucose, high fructose corn syrup, corn syrup, xylose, arabinose, rhamnose, erythritol, xylitol, mannitol, sorbitol, inositol, acesulfame potassium, aspartame, neotame, sucralose, saccharine, or combinations thereof.

Abstract: In a method for aromatizing an alicyclic region of a cannabinoid, especially in enantiopure, scalemic and/or racemic form, in particular for aromatizing the cyclohexene group in ?9-THC-C5, ?9-THCA-C5 A, ?9-THCV-C3, ?9-THCVA-C5 A, and/or scalemic or racemic mixtures of these substances, wherein an oxidizing agent is added to the cannabinoid, sulfur is used as the oxidizing agent.

Abstract: A system and method for seamless access to remotely manage documents using synchronization of locally stored documents are provided. In some embodiments, a content management server stores documents in a cache on the user's computer. Documents can thus be accessed and edited using the document in the local file system of the user and synchronized with the content management server asynchronously to access the documents on the local files system. Advantageously, the teachings of embodiments as described can be used in conjunction with content management systems for providing faster access to documents in conjunction with editing and for enabling offline work on such documents.

Abstract: A system for fastening a horological movement of generally circular shape in a watch case, this fastening system including a casing ring wherein the horological movement is disposed, the casing ring extending between an upper portion and a lower portion, the horological movement being fastened in the lower portion of the casing ring using a first and a second fastening device disposed at two opposite ends of a diameter of the horological movement, at least a third fastening device, angularly offset relative to the first and second fastening device and fastened in the upper portion of the casing ring, allowing the horological movement to be blocked in the casing ring.

Abstract: Preform and manufacturing process producing heterogeneous components with a first fraction (11) made from a first metallic material and having a cellular structure with stochastic or regular cells, and a second fraction (12) made from a second metallic material different from the first metallic material, in which the second fraction (12) at least partly infiltrates the cells of the first fraction (11). The second fraction is poured into the preform which also acts as a mould. The finished product after machining may have a unified surface of the second fraction or several zones exposing the second fraction, the first fraction, the cellular structure which is open or infiltrated with the second metallic fraction, or open zones, in a predetermined design.

Abstract: The method of manufacturing a timepiece shaft (1) includes grinding a ceramic piece, especially to form a balance shaft (1), having a functional portion (2a; 2b) including at least one part (221a; 221b) of a pivot-shank (22a; 22b) and/or at least one part (211a; 211b) of a pivot (21a; 21b), the first functional portion being made of ceramic and a first outer diameter (D1) of the first functional portion being less than 0.5 mm, or less than 0.4 mm, or less than 0.2 mm, or less than 0.1 mm.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for annotation of 3D models with signs of use that are visible in 2D images. In one aspect, methods are performed by data processing apparatus. The methods can include projecting signs of use in a relatively larger field of view image of an instance of an object onto a 3D model of the object based on a pose of the instance in the relatively larger field of view image, and estimating a relative pose of the instance of the object in a relatively smaller field of view image based on matches between the signs of use in the relatively larger field of view image and the same signs of use in the relatively smaller field of view image.