Abstract: Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.
Type:
Grant
Filed:
September 2, 2022
Date of Patent:
August 15, 2023
Assignee:
A-Alpha Bio, Inc.
Inventors:
David Younger, David Colby, Randolph Lopez, Michael Wittekind
Abstract: Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.
Type:
Application
Filed:
August 31, 2022
Publication date:
April 6, 2023
Applicant:
A-Alpha Bio, Inc.
Inventors:
David Younger, Randolph Lopez, Arpita Sen, Ryan Emerson
Abstract: Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.
Type:
Application
Filed:
September 2, 2022
Publication date:
January 5, 2023
Applicants:
A-Alpha Bio, Inc., Olympic Protein Sciences LLC
Inventors:
David Younger, David Colby, Randolph Lopez, Michael Wittekind
Abstract: Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.
Abstract: Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.
Type:
Grant
Filed:
December 16, 2021
Date of Patent:
October 18, 2022
Assignee:
A-Alpha Bio, Inc. et al
Inventors:
David Younger, David Colby, Randolph Lopez, Michael Wittekind
Abstract: Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.
Type:
Grant
Filed:
November 1, 2021
Date of Patent:
October 11, 2022
Assignee:
A-ALPHA BIO, INC.
Inventors:
David Younger, Randolph Lopez, Arpita Sen, Ryan Emerson