Abstract: New improved formulations are described, comprising at least one composition, with or without another composition (at least one second composition), in which the at least one composition, a first composition, is an inhibitor of lipid A deacetylase resulting in permeabilization of an outer membrane of a susceptible microorganism to which it is provided to. The at least one second composition may be a streptogramin. The first composition, alone or in combination with another, may be used to improve and/or treat a wide variety of bacterial infections, providing, on its own better efficacy, bioavailability, and/or pharmacokinetics, as compared with at least other or alternative inhibitors of lipid A deacetylase, as well as no expected cardiotoxicity. When provided to a susceptible microorganism as a combination described herein, the combination may be provided independently or may be provided together (co-combined in a same formulation, or in different formulations).

Abstract: Novel antimicrobial compositions comprise at least a form of a fosfomycin (or suitable analogs, or derivatives thereof), and at least one sulfonamide (or suitable analogs, or derivatives thereof), and/or at least one diaminopyridine (or suitable analogs, or derivatives thereof). Said antimicrobial compositions generally include two or more of said components as a novel combination, provided in a single combination or formulation, or provided independently with overlapping exposures of the two or more components. These novel compositions, when provided as the two or more components, are effective against susceptible microorganisms, and are effective against susceptible drug-resistant microorganisms (e.g., bacteria, parasites), including multi-drug resistant bacteria.

Abstract: A compound of general formula I wherein A is selected from the group of an unbranched or branched alky group with 1 to 12 carbon atoms, an —R1—O—R2 group, an —R1—Si(R3R4R5) group, an —R1—O—Si(R3R4R5) group, a —C(O)—O—R9—Si(R3R4R5) group, a —CH(O—R6)(O—R7) group, an —R1—CH(O—R6)(O—R7) group, or an —R1—O—C(O)—O—R8 group; SG is a protective group; R1 is a divalent hydrocarbon residue with 1 to 12 carbon atoms; R2 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R3, R4 and R5 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R6 and R7 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R8 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms; and R9 is a divalent hydrocarbon residue with 1 to 12 carbon atoms.

Abstract: An electro-optical device for taking flow measurements includes a measurement tank through which a flow of fluid to be characterized flows, at least first and second guns for emitting light having separate spectra, a triggering gun allowing diffraction to be measured at small angles and a receiving gun allowing a measurement of attenuation and at least one fluorescence to be taken. The first emitting gun includes a light source defining a main optical axis perpendicular to the fluid flow, and the second emitting gun includes a second light source defining a secondary optical axis substantially orthogonal to the main optical axis and fluid flow. The first and second emitting guns are placed on one side of the measurement tank, the receiving gun is placed on the other side of the measurement tank along the main optical axis and the triggering gun is placed on the other side of the tank.

Abstract: The present invention relates to novel compounds that bind to the prostate-specific membrane antigen (PSMA)-binding and their use in the diagnosis and treatment of certain diseases where PSMA is upregulated.

Abstract: Co-agent combinations and/or formulations herein unexpectedly display significantly better antimicrobial activity (e.g., more efficacy and/or more potency) against anaerobic pathogens not previously considered targets. With three or more co-agents, selected from a group of a fosfomycin, a diaminopyridine, a sulfonamide, a beta lactam antibacterial, a bacterial beta-lactamase inhibitor, a bacterial fosfomycin-modifying enzyme, and a bacterial peptidoglycan synthesis inhibitor, the therapeutic potential of the three or more co-agents is expanded by targeting a broader spectrum of pathogens. Co-agents, by unexpected synergistic action in an anaerobic environment, are now active and efficacious against difficult to treat pathogenic anaerobes (including anaerobes that cannot utilize oxygen and/or reside in an anaerobic environment, some being inhibited by oxygen), as well as pathogens considered resistant or intolerant to at least one of the co-agents when used singly in an anaerobic environment.

Abstract: An edible composition, an aerosol composition, a flavor composition, a fragrance composition, or an inhalable composition includes an organosulfur compound such as prenyl mercaptan, 2-methylthiophene, 3-methylthiophene, dimethyl disulfide, diprenyl disulfide, 3-methyl-2-buten-1-yl thiolacetate, 3-methyl-1-[(3-methyl-2-buten-1-yl)sulfanyl]-2-butene, prenylmethylthiol (1-(methylsulfanyl)-3-methyl-2-butene), prenyl thioacetate, thiogeraniol, dimethyl sulfide, or a combination of any two or more thereof, and a primary terpene compound selected from the group consisting of myrcene, ?-caryophyllene, limonene, ?-pinene, ?-pinene, valencene, ocimene, terpinolene, or a combination of any two or more thereof.

Abstract: A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

Abstract: An electro-optical device for taking flow measurements includes a measurement tank through which a flow of fluid to be characterized flows, at least first and second guns for emitting light having separate spectra, a triggering gun allowing diffraction to be measured at small angles and a receiving gun allowing a measurement of attenuation and at least one fluorescence to be taken. The first emitting gun includes a light source defining a main optical axis perpendicular to the fluid flow, and the second emitting gun includes a second light source defining a secondary optical axis substantially orthogonal to the main optical axis and fluid flow. The first and second emitting guns are placed on one side of the measurement tank, the receiving gun is placed on the other side of the measurement tank along the main optical axis and the triggering gun is placed on the other side of the tank.

Abstract: Novel antimicrobial compositions comprise at least a form of a fosfomycin (or suitable analogs, or derivatives thereof), and at least one sulfonamide (or suitable analogs, or derivatives thereof), and/or at least one diaminopyridine (or suitable analogs, or derivatives thereof). Said antimicrobial compositions generally include two or more of said components as a novel combination, provided in a single combination or formulation, or provided independently with overlapping exposures of the two or more components. These novel compositions, when provided as the two or more components, are effective against susceptible microorganisms, and are effective against susceptible drug-resistant microorganisms (e.g., bacteria, parasites), including multi-drug resistant bacteria.

Abstract: The invention is a method for estimating a representative volume of particles of interest (10 i) immersed in a sample, the sample extending in at least one plane, referred to as the sample plane (P 10), the sample comprising a sphering agent, capable of modifying the shape of the particles, the method comprising the following steps: a) illuminating the sample by means of a light source (11), the light source emitting an incident light wave (12) propagating towards the sample (10) along a propagation axis (Z); b) acquiring, by means of an image sensor (16), an image (I 0) of the sample (10), formed in a detection plane (P 0), the sample being arranged between the light source (11) and the image sensor (16), each image being representative of a light wave (14) referred to as an exposure light wave, to which the image sensor (16) is exposed under the effect of illumination; c) using the image of the sample (I 0), acquired during step b), and a holographic propagation operator, to calculate a complex expression (

Abstract: A device for shaking and sampling biological liquids that is able to take a sample of a biological liquid in a tube including a shaker designed to mix a rack holding one or more tubes by performing a succession of tilting movements between two shaking positions. The shaker is also arranged to tilt beyond the shaking position furthest away from the insertion position of a rack to discharge same by gravity.

Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

Abstract: A biological analysis system comprising at least one inlet and one outlet, at least two biological analysis devices connected to one another by a conveyor defining a closed circuit, each biological analysis device comprising a region for the exchange of tube holding racks with the conveyor. The conveyor and the at least one inlet of the biological analysis system comprise a reader of an identifier of a tube holding rack which reader is designed to communicate an identifier it has read to a controller of the biological analysis system, which controller is designed to apply a specific treatment to a tube holding rack identified by the reader of the conveyor and the identifier of which has not previously been read by the reader of the at least one inlet of the biological analysis system.

Abstract: A biological analysis system comprises at least two biological analysis devices connected to one another by a conveyor defining a closed circuit, each biological analysis device comprising at least one inlet and one outlet for racks of tubes, and at least one exchange region for exchanging racks of tubes with the conveyor, which exchange region is distinct from the inlet and from the outlet. The inlet of at least two biological analysis devices each form an inlet of the biological analysis system for racks of tubes, and the outlet of at least two biological analysis devices each form an outlet of the biological analysis system for racks of tubes. The biological analysis system further comprises a controller designed to command the transfer of a rack of tubes received in the biological analysis system via the conveyor to another biological analysis device according to the operations to be performed on the tubes in that rack and/or according to a respective workload status of the biological analysis devices.

Abstract: A method for characterizing a particle present in a sample, the sample lying between an image sensor and a light source and the sensor lying in a detection plane, includes illuminating the sample with the light source which emits an incident light wave propagating along a propagation axis, and acquiring an image of the sample with the sensor. The sensor is exposed to an exposure light wave. The image includes a plurality of elementary diffraction patterns each corresponding to one particle. The method also includes reconstructing a complex image representative of a complex amplitude of the light wave on a reconstruction surface passing through the sample, based on the acquired image; selecting a region of interest of the complex image corresponding to a particle of interest; forming an extracted image based on the region of interest; and characterizing the particle of interest depending on the extracted region of interest.

Abstract: An edible composition, an aerosol composition, a flavor composition, a fragrance composition, or an inhalable composition includes an organosulfur compound such as prenyl mercaptan, 2-methylthiophene, 3-methylthiophene, dimethyl disulfide, diprenyl disulfide, 3-methyl-2-buten-1-yl thiolacetate, 3-methyl-1-[(3-methyl-2-buten-1-yl)sulfanyl]-2-butene, prenylmethylthiol (1-(methylsulfanyl)-3-methyl-2-butene), prenyl thioacetate, thiogeraniol, dimethyl sulfide, or a combination of any two or more thereof, and a primary terpene compound selected from the group consisting of myrcene, ?-caryophyllene, limonene, ?-pinene, ?-pinene, valencene, ocimene, terpinolene, or a combination of any two or more thereof.

Abstract: A device for preparing a solution from a sample and a reagent, the device includes a microfluidic array having a sample supply inlet, a reagent supply inlet, a discharge outlet, a solution collection outlet, a sampling zone to which the inlets are connected, first and second preparation chambers connected to the sampling zone, arranged to either side of the sampling zone such that the liquid flowing from one preparation chamber to the other flows through the first sampling zone, the first preparation chamber having a volume that is variable between a minimum volume and a calibrated volume. The device includes valves interrupting the flow of the fluid at least at the two inlets and the collection and discharge outlets.

Abstract: The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.

Abstract: Rotary position sensors are provided. In one example implementation, a rotary position sensor can include a first member and a second member, one of the first and second members having a transmit aerial and a receive aerial and the other of the first and second members having an intermediate coupling element. The receive aerial has at least one receive conductive winding arranged to form a first set of current loops and a second set of current loops. The intermediate coupling element comprises a conductive material arranged in a pattern. The pattern of the intermediate coupling element and the layout of the first and second set of current loops are mutually arranged such that any electromotive force induced in the first set of current loops by a background magnetic field is substantially balanced by an electromotive force induced in the second set of current loops by the background magnetic field.