Abstract: The present invention relates to a pharmaceutical composition for the treatment of cancer as well as methods of treatment of cancer that are based on the finding that certain benzimidazole based anti-cancer agents can be used in combination with a second anti-cancer agent to achieve desirable therapeutic outcomes. More specifically the present invention relates to a pharmaceutical composition including a benzimidazole based anti-cancer agent and a second anti-cancer agent. The invention also relates to methods of treatment of cancer including administration of a benzimidazole based anti-cancer agent and a second anti-cancer agent to a patient in need thereof.
Type:
Application
Filed:
March 7, 2008
Publication date:
April 22, 2010
Applicant:
S'BIO PTE LTD
Inventors:
Kay Lin Goh, Hwee Hoon Khng, Vasantha Malar Sabanayagam, Kanda Sangthongpitag, Walter Stunkel, Yong Cheng Tan, Jeanette Marjorie Wood
Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other conditions or disorders associated with kinases.
Type:
Application
Filed:
November 15, 2006
Publication date:
October 15, 2009
Applicant:
S*BIO Pte Ltd.
Inventors:
Stephanie Blanchard, Kantharaj Ethirajulu, Cheng Hsia Angeline Lee, Harish Kumar Mysore Nagaraj, Anders Poulsen, Eric T. Sun, Yee Ling Evelyn Tan, Ee Ling Teo, Anthony Deodaunia William
Abstract: A water treatment process comprising: (a) providing bioactive material in waste water, the bioactive material containing microorganisms capable of removing one or more impurities from the waste water, wherein at least 40% by volume of said bioactive material in said waste water is in granular form; and (b) passing a portion of the waste water through a membrane separator, whereby the membrane separator prevents the bioactive material from passing therethrough.
Type:
Application
Filed:
July 6, 2005
Publication date:
May 21, 2009
Applicant:
GLOWTECH BIO PTE LTD
Inventors:
Tze Guan Ong, Stephen Tiong Lee Tay, Joo Hwa Tay
Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.
Type:
Application
Filed:
November 15, 2006
Publication date:
March 19, 2009
Applicant:
S*BIO Pte Ltd.
Inventors:
Stephanie Blanchard, Cheng Hsia Angeline Lee, Harish Kumar Mysore Nagaraj, Anders Poulsen, Eric T. Sun, Yee Ling Evelyn Tan, Anthony Deodaunia William
Abstract: The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
Type:
Application
Filed:
August 1, 2006
Publication date:
February 19, 2009
Applicant:
S*BIO Pte Ltd.
Inventors:
Dizhong Chen, Weiping Deng, Ken C. Lee, Pek L. Lye, Eric T. Sun, Haishan Wang, Niefang Yu
Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to acylurea/sulfonylurea containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities.
Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to biaryl containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities. Formula (I), where Z is a single bond or C1-C4 hydrocarbon, A is an aromatic ring, B is an aromatic ring.
Type:
Application
Filed:
October 26, 2004
Publication date:
July 19, 2007
Applicant:
A*BIO Pte Ltd.
Inventors:
Walter Stunkel, Haishan Wang, Zheng Yin
Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
Type:
Application
Filed:
September 21, 2004
Publication date:
February 22, 2007
Applicant:
S*BIO Pte Ltd.
Inventors:
Dizhong Chen, Weiping Deng, Kanda Sangthongpitag, Hong Song, Eric Sun, Niefang Yu, Yong Zou