Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of cancers, particularly cancers that exhibit elevated expression of FOXA1 and/or FOXA1 gene targets, such as certain breast, liver and/or prostate cancers, including luminal and/or ER-positive forms of breast cancer. Three previously identified adenosine receptor antagonists, CGS-15943, MRS-1220 and SCH-58261, as well as furan ring moiety-possessing derivatives of CGS-15943 are specifically provided for killing cancer cells in a manner that appears to involve activation of the aryl hydrocarbon receptor (AHR) by such compounds. The instant disclosure therefore provides for selecting and/or administering CGS-15943, MRS-1220, SCH-58261 and/or a furan-possessing derivative of CGS-15943, MRS-1220 and/or SCH-58261 as a therapeutic agent to target a cancer cell and/or subject having or at risk of developing a cancer. Methods and compositions for therapies that include such compounds are also provided.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of microsatellite unstable cancers. In particular, the instant disclosure provides for identification of a cancer as exhibiting microsatellite instability (MSI) and/or impaired mismatch repair (MMR), and selection and/or administration of an inhibitor of the WRN helicase as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.

Abstract: A polycrystalline magnetocaloric material based on thermally annealed Fe100-xRhx melt-spun ribbons with chemical composition x in the interval 48?x?52 at. % and the bcc CsCl-type crystal structure (B2) and method for manufacturing the same. The material has improved magnetocaloric properties associated to first-order magneto-elastic phase transition compared to bulk alloys of similar chemical composition manufactured by conventional melting techniques; exhibiting both low-magnetic field induced giant magnetocaloric effects and enhanced refrigeration capacity close to the room temperature range, due to the fast increase of a magnetic entropy change at low fields that is followed by a broad table-like magnetic entropy change as function in the temperature curve.

Abstract: A matrix formulated with probiotics, which can be used to reduce the development of caries by inhibiting Streptococcus mutans and wherein the probiotics include: 3-5 g/100 mL pectin; 6-9 g/100 mL dextrose; 25-50 mg/100 mL citric acid; 2-4 mL/100 mL natural flavouring; and 4×10 12 CFU/mL of the microorganisms Streptococcus salivarius and Lactobacillus plantarum in active state. The matrix is administered to a patient to prevent dental caries.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.

Abstract: Provided is one gene CpRap2 isolated from Carica papaya identified as CpRap2.4b and that includes SEQ. ID NO: 2, as well as the genetic transformation methods for the overexpression of said gene and the obtaining of tolerant non-transgenic plants through grafts. Genetic transformation of plants that overexpress genes CpRap2 and their grafts showed they could survive extreme temperatures up to 12 days for heat and more than 30 days for cold.

Abstract: A system and method for optical sectioning in bright field microscopy (OSBM). The system includes a bright field optical microscope having automated change of focus, a substage condenser fitted with an adjustable aperture iris diaphragm, a digital camera that records the microscope image of samples, and one or more digital computers to perform digital image processing. The OSBM method comprises operating the microscope to Kohler illumination, using the iris diaphragm of the condenser to generate contrast in images, acquiring a Z-stack of images of the unstained sample, and applying a sequence of digital image processing filters to the Z-stack, resulting in optical sections from where the final three-dimensional (3D) image of the sample can be reconstructed by computational device. The final 3D images produced by this invention present quality comparable to that of available optical sectioning techniques that require sample labeling, such as light sheet fluorescence microscopy.

Abstract: The present disclosure relates to compositions and methods related to bicyclo[2.2.1] heptanamine-containing compounds and salts.

Abstract: The invention relates to a method for producing particles with pore structures, by means of a hybrid process of atomization via drying-cooling, from a water-in-oil-type emulsion of a composition of a non-solubilized and in melt state matrix. The production method comprises: i) forming a water-in-oil-type emulsion consisting of a composition of a solvent that is aqueous or soluble in water (dispersed phase) and a composition of a non-solubilized and in melt state matrix (continuous phase); ii) forming discrete particles from the emulsion via atomization, using a flow of gas at high pressure and temperature; iii) immediately removing the solvent via evaporation; and iv) subsequently cooling the formed discrete particles, resulting in porous particles that are substantially free from solvents.

Abstract: A system and method for optical sectioning in bright field microscopy (OSBM). The system includes a bright field optical microscope having automated change of focus, a substage condenser fitted with an adjustable aperture iris diaphragm, a digital camera that records the microscope image of samples, and one or more digital computers to perform digital image processing. The OSBM method comprises operating the microscope to Kohler illumination, using the iris diaphragm of the condenser to generate contrast in images, acquiring a Z-stack of images of the unstained sample, and applying a sequence of digital image processing filters to the Z-stack, resulting in optical sections from where the final three-dimensional (3D) image of the sample can be reconstructed by computational device. The final 3D images produced by this invention present quality comparable to that of available optical sectioning techniques that require sample labeling, such as light sheet fluorescence microscopy.

Abstract: Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods.

Abstract: The present invention relates to fertilizer particles encapsulated in modified chitosan and a method of obtaining them. The particles described in this invention allow a controlled, moderate, or gradual release of an active material from a reserve substrate to another medium, in order to increase the effectiveness of the active material by prolonging its action over time. This invention is characterized in that the active components of said formulations are capable of causing a synergistic effect, considerably increasing the growth and development of plants.

Abstract: Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods. The compounds may have the structure of formula I(a): wherein the substituents are as described in the description; or a pharmaceutically acceptable form thereof.

Abstract: The present invention relates to compositions and methods for targeting cancer-specific DNA sequences, such as copy number amplifications and other types of cancer-specific sequence variations, such as cancer-specific polymorphisms, insertions, or deletions. The present invention provides hereto sequence-specific DNA targeting agents targeting a sequence within the amplified DNA region or a sequence otherwise specific for a cancer cell compared to a non-cancer cell. The invention further relates to methods for treating cancer, comprising administering such sequence-specific DNA targeting agents. The invention further relates to methods for preparing sequence-specific DNA targeting agent, as well as screening methods using the DNA targeting agents.

Abstract: A device and method based on an active anti-islanding technique for Distributed Power Generator Systems. The present invention is based on the Sandia Voltage Shift (SVS) technique, which includes a small Non-Detection Zone (NDZ) and by an acceptable solution to the tradeoff between the output power quality and the effectiveness of islanding detection. The present invention has the advantage to improve the NDZ and to reduce the anti-islanding detection times. This is due to the exponential-product modification made in the positive feedback to inject current, thereby making the response faster than SVS. Additionally, a self-adaptive gain is considered to achieve a low Total Harmonic Distortion (THD) at different power levels.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of microsatellite unstable cancers. In particular, the instant disclosure provides for identification of a cancer as exhibiting microsatellite instability (MSI) and/or impaired mismatch repair (MMR), and selection and/or administration of an inhibitor of the WRN helicase as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.

Abstract: The hereby invention provides four genes CpRap2 isolated from Carica papaya identified as CpRap2.4a, CpRap2.4b, CpRap2.1, CpRap2.10 and that consist of SEQ. ID NO: 1, SEQ. ID NO: 2, SEQ. ID NO: 3 and SEQ. ID NO: 4, as well as the genetic transformation methods for the overexpression of these genes and the obtaining of tolerant non-transgenic plants through grafts. Genetic transformation of plants that overexpress genes CpRap2 and their grafts showed they could survive extreme temperatures up to 12 days for heat and more than 30 days for cold.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of EGLN1-dependent cancers. In particular, the instant disclosure provides for identification of a cancer as EGLN1-dependent, and selection and/or administration of an inhibitor of EGLN1 or VHL (Von Hippel-Lindau Tumor Suppressor) as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.

Abstract: A polycrystalline magnetocaloric material based on thermally annealed Fe100-xRhx melt-spun ribbons with chemical composition x in the interval 48?x?52 at. % and the bcc CsCl-type crystal structure (B2) and method for manufacturing the same. The material has improved magnetocaloric properties associated to first-order magneto-elastic phase transition compared to bulk alloys of similar chemical composition manufactured by conventional melting techniques; exhibiting both low-magnetic field induced giant magnetocaloric effects and enhanced refrigeration capacity close to the room temperature range, due to the fast increase of a magnetic entropy change at low fields that is followed by a broad table-like magnetic entropy change as function in the temperature curve.