Abstract: Digital pathology is a promising alternative to manual slide analysis, but improvements in imaging and analysis methods are needed to provide an analysis data set of images that can easily be handled, stored, and importantly, delivered from one data location to another. Methods and software are described herein to improve image collection and analysis.

Abstract: A system for facilitating image finding analysis includes one or more processors and one or more hardware storage devices storing instructions that are executable by the one or more processors to configure the system to perform acts such as (i) presenting an image on a user interface, the image being one of a plurality of images provided on the user interface in a navigable format, (ii) obtaining a voice annotation for the image, the voice annotation being based on a voice signal of a user, and (iii) binding the voice annotation to at least one aspect of the image, wherein the binding modifies metadata of the image based on the voice annotation.

Abstract: Described herein are computer-implemented methods for compressing sparse multidimensional ordered series data. In particular, these methods and apparatuses for performing them (including software) may be particularly well suited to efficiently compressing spectrographic data.

Abstract: Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. The method involves using a measured spectrum of data from a sample taken with a mass spectrometer, deconvoluting the measured spectrum of data by applying parsimony weighting to minimize the number of charge states based on one or more of: the number of intense peaks in the mass spectrum; the number of harmonic relationships (e.g., masses in small integer ratios); and the number of off-by-one relationships (e.g., m/z bins with high probability for two adjacent charges). Thus, the underlying m/z spectrum may be inferred from the family of plausible deconvoluted spectra determined by applying parsimony and the inferred m/z spectrum may be used to identify and/or characterize the sample.

Abstract: Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. Methods may include analyzing spacings between mass-to-charge ratio peaks from measured mass spectrum data, identifying and associating the spacings with mass delta values corresponding to masses of possible constituents of a molecule within the sample, calculating estimated charges of molecular species within the sample based on the spacings and mass delta values, and deconvoluting the measured mass spectrum data based on the estimated charges to provide a neutral mass spectrum. The methods and apparatuses (including software) described herein may result in more accurate characterization of peaks within the neutral mass spectrum, less false peaks within the neutral mass spectrum, and less noise in the neutral mass spectrum.

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising interactive and dynamic selection of one or more masses and concurrent display of peaks (points) corresponding to that predicted mass value across other displays (MS1, deconvolved mass spectrum, etc.).

Abstract: A computer-implemented method for determining and evaluating an objective tumor response to an anti-cancer therapy using cross-sectional images can include receiving cross-sectional images of digital medical image data and identifying target lesions within the cross-sectional images. For each of the target lesions, a target lesion type and anatomical location is identified, a segmenting tool is activated for segmenting the target lesions into regions of interest, lesion metrics are automatically extracted from the regions of interest according to tumor response criteria, and conformity of target lesion identification is monitored using rules associated with the tumor response criteria, prompting a user to address any nonconforming target lesion. The method also includes receiving a presence/absence of metastases, determining changes in lesions metrics, and deriving an objective tumor response based on the tumor response criteria.

Abstract: A system for facilitating lesion analysis accesses a first data structure comprising a plurality of entries including anatomic location information and annotation information associated with a plurality of lesions represented in a first set of cross-sectional images. The system displays a respective representation of each of the plurality of entries and presents a second set of cross-sectional images. The system receives user input triggering selection of a particular entry of the plurality of entries of the first data structure.

Abstract: An immersion probe system is provided for simultaneously performing first analysis of a first portion of light originating from liquids and/or particles in a fluid and second analysis of a second portion of the light originating from the liquids and/or particles. The system defines an optical axis and includes a first component including a first analyzer, a window, and a first optical path extending between the window and the first analyzer. The system also includes a second component including a second analyzer, the window, and a second optical path extending between the window and the second analyzer. The system further includes a spectral selector placed in the first optical path and in the second optical path to direct the first portion of the light, which originates from the liquids and/or particles and passes through the window, to the first analyzer, and to direct the second portion of said light to the second analyzer.

Abstract: A system for facilitating lesion analysis accesses a first data structure comprising a plurality of entries including anatomic location information and annotation information associated with a plurality of lesions represented in a first set of cross-sectional images. The system displays a respective representation of each of the plurality of entries and presents a second set of cross-sectional images. The system receives user input triggering selection of a particular entry of the plurality of entries of the first data structure.

Abstract: A system for facilitating lesion analysis is configurable to identify a user profile associated with a user accessing the system. The user profile indicates a radiology specialty associated with the user. The system is also configurable to access a plurality of cross-sectional medical images associated with a particular patient and identify a subset of cross-sectional medical images from the plurality of cross-sectional medical images that correspond to the radiology specialty indicated by the user profile. The system is also configurable to present the subset of cross-sectional medical images to the user in navigable form.

Abstract: A system for facilitating lesion analysis accesses a first data structure comprising a plurality of entries including anatomic location information and annotation information associated with a plurality of lesions represented in a first set of cross-sectional images. The system displays a respective representation of each of the plurality of entries and presents a second set of cross-sectional images. The system receives user input triggering selection of a particular entry of the plurality of entries of the first data structure.

Abstract: A computer-implemented method for determining and evaluating an objective tumor response to an anti-cancer therapy using cross-sectional images can include receiving cross-sectional images of digital medical image data and identifying target lesions within the cross-sectional images. For each of the target lesions, a target lesion type and anatomical location is identified, a segmenting tool is activated for segmenting the target lesions into regions of interest, lesion metrics are automatically extracted from the regions of interest according to tumor response criteria, and conformity of target lesion identification is monitored using rules associated with the tumor response criteria, prompting a user to address any nonconforming target lesion. The method also includes receiving a presence/absence of metastases, determining changes in lesions metrics, and deriving an objective tumor response based on the tumor response criteria.

Abstract: When different client devices request the same document, most of content of the response from the server (i.e. the response document from a web server) will be the same. Embodiments allow the client devices to use fingerprints, i.e. hashes, sent by a capture system to pinpoint only the changing portions of the document instead of sending the entire document. In various embodiments, the client compares client-generated fingerprints for the document with capture system-generated fingerprints for most likely appearing portions of text of the document or related documents to fully represent and sends to the capture system the client document in a compact and efficient way.

Abstract: The present invention relates generally to a system and methods for the selection and use of content. More specifically, the present invention relates to a system and methods through the use of which information of one or more types and from one or more information sources may be selected, accessed, analyzed, and managed in order to extract content from which synthesized information may be developed that may be used to produce an information product relevant to a selected topic, issue, subject, or other target. Certain embodiments of the present invention are configurable to permit a user to identify the target for which the synthesized information is sought, select the source or sources from which the information is drawn, identify content in the information relevant to the target to produce the synthesized information, and select the detail of and the form in which the synthesized information is presented in order to produce a customized information product.

Abstract: The present disclosure describes how to capture events (e.g., changes and user interactions) of a Web document and combine those changes with the original DOM displayed to accurately and efficiently enable a replay engine to redisplay the DOM, changes, and user interactions which occurred within a user's browser. The data collected from a client-side HTML DOM capture engine can be combined with a minimal amount of contextual information to a replay engine so as to accurately and efficiently replay a session of a plurality of web documents.

Abstract: The present disclosure describes how to capture events (e.g., changes and user interactions) of a Web document and combine those changes with the original DOM displayed to accurately and efficiently enable a replay engine to redisplay the DOM, changes, and user interactions which occurred within a user's browser. The data collected from a client-side HTML DOM capture engine can be combined with a minimal amount of contextual information to a replay engine so as to accurately and efficiently replay a session of a plurality of web documents.

Abstract: An improved system and methods for identifying, assessing, obtaining, evaluating, processing and displaying information about specific topics of interest. In certain embodiments, information is processed with advanced computation and analytical techniques in which detailed statistical data is generated and refined to produce meaningful quantitative and qualitative information that may be useful in analyzing the economic performance of specific businesses or geographical regions of interest.

Abstract: The present invention relates generally to gathering, verifying, and providing information in an easy-to-understand format. Representations are obtained and evaluated to extract selected content or content information from which certain synthesized information can be gathered, collected, estimated, calculated, or determined. In addition, supplemental synthesized information may be gathered, collected, estimated, calculated, or determined.

Abstract: Techniques are disclosed for capturing, storing, and regenerating a view of content in applications (e.g., native applications) on devices (e.g., a mobile device). In at least one embodiment, a capture management system is disclosed that produce compact data storage of views of content in an application on a device and the efficient search thereof of views of content provided in the application. The views of content can be translated into a transportable data layer, such as HTML, and captured using delta encoding to identify changes and modifications in content accessed in any application at a device. A capture management system can accurately and efficiently capture events displayed for an application at a device and send the events to a server-side system, which can combine the events to reassemble the events. For example, user interface and user interaction events on an application at a mobile device can be reassembled for the purpose of playback and analysis of interactions with the application.