Patents Assigned to A. Natterman & Cie. GmbH
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Patent number: 6663885Abstract: An aqueous liposome system comprises at least one phospholipid, a non-phospholipidic substance which is a bile acid or derivative thereof, and, optionally, a non-toxic organic solvent. The mass ratio of phospholipid to the non-phospholidic substance is in the range between 1:0.001 and 1:0.1. The diameter of the liposomes formed in this liposome system is in the range between 35 and 90 nm. The liposome system is stable over large periods of time, e.g., several months or years, and is highly transparent. The liposomes may be loaded with a pharmaceutically active ingredient.Type: GrantFiled: March 7, 1996Date of Patent: December 16, 2003Assignee: A. Natterman & Cie GmbHInventors: Jörg-Christian Hager, Josef-Peter Löhr, Manfred Dürr
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Patent number: 6495517Abstract: A cyclooxygenase-2-inhibitor containing as an active ingredient a compound having cyclooxygenase-2-inhibitory activity and exhibiting low toxicity that causes only minor side effects. The active compound is represented by the following formula (1) or (1′): wherein R1 represents a hydrogen atom or a C1-C3 alkyl group; R2 represents a hydrogen atom, a hydroxyl group, an organic group capable of being bound through its thiol group within the molecule, or R1 and R2 may join to each other to form a single bond; R3 represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group, a C1-C3 alkoxyl group, a trifluoromethyl group, or a nitro group; each of R4 and R5, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a C1-C4 alkoxyl group, a trifluoromethyl group, or R4 and R5 may join to each other to form a methylenedioxy group.Type: GrantFiled: April 20, 2001Date of Patent: December 17, 2002Assignee: A. Natterman & Cie. GmbHInventor: Zyunji Tanaka
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Publication number: 20010027176Abstract: A cyclooxygenase-2-inhibitor containing as an active ingredient a compound having cyclooxygenase-2-inhibitory activity and exhibiting low toxicity that causes only minor side effects.Type: ApplicationFiled: April 20, 2001Publication date: October 4, 2001Applicant: A. Natterman & Cie. GmbHInventor: Zyunji Tanaka
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Patent number: 5741513Abstract: An alcoholic, aqueous gel-like phospholipid composition is disclosed which contains, as alcohols, ethanol, 1-propanol or 2-propanol, which is characterized in that this composition is a liposomal gel composed of 15.00 to 30.00 parts by weight of a phospholipid concentrate, 14.00 to 20.00 parts by weight of alcohol and 50 to 71.00 parts by weight of an aqueous solution as the remainder. The use of this phospholipid composition for the preparation of liposomal solutions by dilution with a solution and topical preparations which contain these solutions are additionally disclosed.Type: GrantFiled: June 7, 1995Date of Patent: April 21, 1998Assignee: A. Natterman & Cie. GmbHInventors: Miklos Ghyczy, Joachim Roding, Hans Lautenschlager, Walter Hameister, Jorg Hager
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Patent number: 5711965Abstract: An alcoholic, aqueous gel-like phospholipid composition is disclosed which contains, as alcohols, ethanol, 1-propanol or 2-propanol, which is characterized in that this composition is a liposomal gel composed of 15.00 to 30.00 parts by weight of a phospholipid concentrate, 14.00 to 20.00 parts by weight of alcohol and 50 to 71.00 parts by weight of an aqueous solution as the remainder. The use of this phospholipid composition for the preparation of liposomal solutions by dilution with a solution and topical preparations which contain these solutions are additionally disclosed.Type: GrantFiled: February 21, 1996Date of Patent: January 27, 1998Assignee: A. Natterman & Cie. GmbHInventors: Miklos Ghyczy, Joachim Roding, Hans Lautenschlager, Walter Hameister, Jorg Hager
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Patent number: 5248798Abstract: The invention refers to a novel method for the preparation of 8-hydroxyoctanoic acid by reaction of 6-chlorohexanol with a dialkyl malonate ester, thermal decarboxylation of the malonic acid derivative and isolation of the 8-hydroxyoctanoic acid as the free acid or as an alkali metal salt.Type: GrantFiled: July 22, 1991Date of Patent: September 28, 1993Assignee: Natterman, A. & Cie. GmbHInventors: Bernd R. Gunther, Rainer Losch, Hans Lautenschlager, Klaus Steiner
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Patent number: 4687766Abstract: Pharmaceutical preparation containing phospholipids for the therapeutic treatment of rheumatic diseases which contain in addition to the antiphlogistically acting oxicam derivatives of the general formula ##STR1## special 1,2-diacyl-glycero-3-phosphocholines wherein 75-86% by weight of the acyl radicals are unsaturated fatty acid radicals, and the preparation thereof.Type: GrantFiled: December 21, 1984Date of Patent: August 18, 1987Assignee: A. Natterman & Cie, GmbHInventors: Armin Wendel, Sigurd Leyck, Helmut Wetzig, Jorg Hager, Manfred Durr, Miklos Ghyczy
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Patent number: 4643998Abstract: The invention relates to new imidazolylalkylthienyltetrahydropyridazines of the general formula I ##STR1## their acid addition salts as well as processes for their use in the treatment of cardiovascular and/or thromboembolic illnesses in humans.Type: GrantFiled: October 26, 1983Date of Patent: February 17, 1987Assignee: A. Natterman & Cie GmbHInventors: Gerd Hilboll, Gerrit Prop, Harald Borbe, Josef P. Lohr, Ille-Stephanie Doppelfeld
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Patent number: 4567161Abstract: Liquid, active substance formulations containing an active substance insoluble or poorly soluble in water, or a mixture, a phospholipid, a special co-emulsifier (glycerinester in which the 1 or 2 OH groups have been esterized with hydrocarbon atoms of 8-16, preferably 8-10, C atoms by means of fatty acids and the 3 or remaining OH group of the glycerin body has been etherized with polyethyleneglycol, specifically, with 6-30, preferably 6-15 ethyleneoxide units) and a liquid carrier, the molar ratio of phospholipid to co-emulsifier being from 1:1 to 1:4, and the formulations being such that when added to water they form a transparent liquid system in the form of a microemulsion, with a degree of fineness of 10-200 nm in the lipid phase.Type: GrantFiled: June 28, 1983Date of Patent: January 28, 1986Assignee: A. Natterman & Cie GmbHInventors: Ulrich Posanski, Miklos Ghyczy, Kurt-Heinz Bauer, Armin Wendel
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Patent number: 4528193Abstract: A novel pharmaceutical composition is provided which is suitable for the prevention of inflammation and which comprises a non-steroidal inflammation-preventing compound (e.g. pyrazolones, salicyclic acid derivatives, indoles, indanes, and phenylacetic acid and anthranilic acid derivatives) and at least one phospholipid.Type: GrantFiled: November 7, 1983Date of Patent: July 9, 1985Assignee: A. Natterman & Cie. GmbHInventors: Miklos Ghyczy, Adorjan Erdos, Gunter Heidemann, Gotz Ritzmann
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Patent number: 4497158Abstract: The present invention is related to a process for filling pharmaceutical products which are highly viscous at room temperature, into hard capsules by admixing to such products a solvent or mixture of solvents in particular amounts, said solvent or solvent mixture having particular evaporation properties, and ejecting the resulting product from a usual filler nozzle under particular conditions, and closing the filled capsule with its cap.Type: GrantFiled: June 2, 1981Date of Patent: February 5, 1985Assignee: A. Natterman & Cie GmbHInventors: Manfred Durr, Hans-Ulrich Fribolin