Abstract: A mask for use at an operating pressure substantially equal to atmospheric pressure includes a body with a three-dimensional shaped chamber that is configured to receive a user's mouth and nares and operate at the operating pressure. The mask also includes a seal forming structure with a nose seal portion that extends around at least a portion of the user's nares on an inferior side of the user's nose inferior to the user's nasal ridge, and a mouth seal portion that forms a seal at least partially around the user's mouth and between the user's chin and lip inferior. The nose seal portion is directly connected to the mouth seal portion. The mask also includes a positioning and stabilising structure to provide a force to hold the seal forming structure in position against the user.

Abstract: An online insurance system including a customer interface, configured to enable an insurance customer to enter insurance claim details, a tradesperson interface, configured to enable a tradesperson to provide cost estimates based at least in part on the insurance claims details, and an assessor interface, configured to enable an assessor to review the claim provided by the customer; and the cost estimates provided by the tradesperson.

Abstract: A display and interaction method in a user interface is provided. A display region is provided on the user interface for displaying a plurality of interactive items on a track. The track extends along a path created between an outer elliptical border and an inner elliptical border. The inner border lies within the outer border and a center of the inner border is offset from a center of the outer border. A plurality of elliptical frames are provided along the track, and each frame is in contact with the inner border, outer border, and its adjacent frames. An interactive item is displayed in some of the elliptical frames, and user input may move the frames along the track. The frames change in size as they move along the track.

Abstract: A rock anchor assembly includes: a tubular sleeve between first and second ends, having an anchor retaining portion opening on the second end; a rock anchor with an elongate body extending between distal and proximal ends, received in the tubular sleeve with the proximal and distal ends of the body projecting from the first and second ends respectively of the sleeve; a tensioning and locking assemblage on the anchor body between the proximal end and the first end of the sleeve, a forward part being engageable with the first end of the sleeve; and a mechanical anchor engaged to the anchor body at the distal end which, from an unexpanded configuration, expands radially to an expanded configuration. The anchor retaining portion at least partially retains the mechanical anchor in the unexpanded configuration. The anchor retaining portion expands circumferentially to accommodate retracted ingress of the anchor in the expanded configuration.

Abstract: The preferred invention is directed to a controller for a vehicle exhaust valve. The controller comprises a vehicle interface for determining a live value for an operating parameter of a vehicle, a recording module being configured to, upon activation, instantaneously record the live value of the operating parameter, and a programming module for determining a value range based on the recorded live value and allowing a desired position of the valve to be set such that during operation, the control system automatically moves the valve to the desired position when the operating parameter is within the value range.

Abstract: A management system for a commercial electric vehicle (EV), comprising: a controller area network (CAN) comprising a plurality of CAN buses connected to a plurality of components of the EV; and a vehicle controller connected to the CAN and configured to monitor and/or control the plurality of components of the EV based on CAN signals; wherein the plurality of CAN buses and their respective components comprise: a drive CAN bus connected to a motor controller system; a battery CAN bus connected to a battery system; and a telematics CAN bus connected to a telematics system.

Abstract: A respiratory system is configured to pressurize and deliver a flow of respiratory gas to a patient's airways. The respiratory system includes a cushion configured to sealingly engage the patient's face and a blower mounted to the cushion and configured to pressurize a flow of respiratory gas. An interface structure is attached to an outlet of the blower and an aperture in the cushion. The interface structure forms a gas flow path between the cushion and the blower. The gas flow path is configured to deliver the pressurized respiratory gas from the blower through the aperture in the cushion. The gas flow path is also configured to vent exhaled gas from the aperture in the cushion to atmosphere. The respiratory system also includes headgear configured to support the cushion and the blower on the patient's face.

Abstract: The present invention relates to a combination therapy for tumours comprising the administration of an epoxytigliane compound and an immune checkpoint inhibitor. In particular embodiments, there is a method of treating a tumour and/or treating or preventing one or more bystander tumours with the therapy. Pharmaceutical compositions and kits containing epoxytigliane compounds and immune checkpoint inhibitors are also described.

Abstract: A method of communicating between an operator server and a user device for recording audio and/or video data includes the operator server receiving video data and/or audio data from the user device; the operator server initiating a session with an operator interface, wherein the session is initially in a pre-interaction mode and in response to receiving an instruction from the operator interface to change the session to an interaction mode, control the operator interface in order to change the session to an interaction mode, wherein, when in the interaction mode, a user of the user device and an operator of the operator interface are enabled to communicate with one another. The operator server is configured to begin recording of the video data and/or audio data before controlling the operator interface to change to the interaction mode and to continue recording received video data and/or audio data after said change.

Abstract: Apparatus and methods for monitoring pregnancy or labour are disclosed. In one embodiment the apparatus includes an electromyography (EMG) sensor having two or more EMG electrodes to monitor fetal or maternal activity during pregnancy or labour and one or more position sensors to monitor the relative positioning of the two or more EMG electrodes during the fetal or maternal activity. In one embodiment, the apparatus includes a monitoring device to be placed on a body and having a plurality of sensors integrated into the monitoring device, the plurality of sensors including at least: a first sensor configured to detect a first type of signal from the body indicative of a first type of fetal or maternal activity during pregnancy or labour; and a second sensor configured to detect a second type of signal from the body, different from the first type of signal, also indicative of the first type of fetal or maternal activity during pregnancy or labour.

Abstract: The disclosed methods are generally directed to preventing, treating, suppressing, controlling or otherwise mitigating side effects of T-cell therapy, the T-cell therapy designed to accelerate immune reconstitution, induce a GVM effect, and/or target tumor cells.

Abstract: A spacing plate for tile lippage control has a base plate and at least one spacing member extending perpendicularly from an upper surface thereof. At least one spacing member comprises a pair of parallel elongate spacer walls defining parallel outer facing spacing control faces and the elongate spacer walls are spaced apart to define an elongate gap therebetween. As such, the spacing members may flexibly slightly to account for slight horizontal misalignments. Furthermore, edges of the baseplate may comprise cutouts dividing the baseplate into independently flexing leaves which can flexibly engage under individual tiles to account for slight vertical misalignments.

Abstract: A method for improving the dissolution profile of a biologically active material

Abstract: A trampoline having a frame and a jumping mat formed in a single piece from woven elasticated material. The trampoline has a flat base portion lower than the periphery of the jumping mat, and an integral side portion continuous with the base portion around the entire periphery thereof and extending to the periphery of the jumping mat. The jumping mat is connected to the frame by at least two biasing connectors to be supported under tension above ground or floor. The frame may include a first circumextending support coupled to the periphery of the jumping mat by at least one biasing connector to support the periphery of the jumping mat above the ground or floor. A circumextending safety enclosure net has first and second portions extending respectively above and below the level of the first circumextending support. the second portion extending to a second circumextending support forming part of the frame.

Abstract: A liquid treatment unit removes particulate matter and colloids from a liquid, as found in waste water on mines, on construction sites and on heavy industry sites. The liquid treatment unit includes an electrocoagulation unit and a cyclonic separator unit. The liquid to be treated is first subject to electrocoagulation and then fed into the cyclonic separator unit. The cyclonic separator unit guides the electrocoagulated liquid in a circular path downwardly from an outer perimeter to move underneath a skirt and then upwardly and inwardly towards a central outlet located at the top of the cyclonic separator. Floating particles are skimmed from the surface outside of the skirt. In moving to the outlet, the liquid passes through a plurality of nested frusto-conical guide members. An ultrasonic transducer is used to collapse bubbles formed by electrocoagulation, and to clean the electrocoagulation electrodes.

Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.