Patents Assigned to A/S Dumex
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Patent number: 6193985Abstract: The present invention provides the use of a tocopherol or a derivative thereof as a solvent and/or emulsifier for substantially insoluble and sparingly soluble biologically active agents, especially in the manufacture of pharmaceutical compositions. Such compositions are particularly suitable for transmucosal, and especially intranasal or rectal administration, or administration via the oral cavity.Type: GrantFiled: May 14, 1997Date of Patent: February 27, 2001Assignee: A/S Dumex (Dumex Ltd)Inventor: Mette Rydahl Sonne
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Patent number: 5538954Abstract: A salt of sucrose-octa-O-sulfonic acid and a tetracycline useful in inhibiting protein synthesis of bacteria.Type: GrantFiled: June 24, 1994Date of Patent: July 23, 1996Assignee: A/S Dumex (Dumex Ltd.)Inventors: Torben Koch, Hjarne Dyrsting
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Patent number: 5433352Abstract: A liquid dispensing device which includes a housing and a spring actuated lever arm hingedly connected to the housing and having a latch operatively connected to a toothed bar wherein upon depression of the lever arm the toothed bar is axially displaced toward the front end of the housing and during return of the lever arm to its original position, the toothed bar is released, wherein the lever arm, the spring and the latch are integral, and the spring and latch are the same element.Type: GrantFiled: November 30, 1993Date of Patent: July 18, 1995Assignee: A/S Dumex (Dumex Ltd.)Inventor: Jorn Ronvig
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Patent number: 5143934Abstract: Controlled delivery of biologically active agents such as pharmaceuticals to body sites is accomplished by combination with a monoglyceride and a vegetable oil. Upon contact with an aqueous liquid, the composition forms a reverse hexagonal liquid crystalline phase matrix which releases the active agent in controlled fashion. The method of delivery is particularly useful for the treatment of periodontal disease by insertion of the liquid crystalline phase precursor composition directly into the periodontal pocket, where water from the gingival fluid induces the spontaneous in situ formation of the reverse hexagonal liquid crystalline phase matrix.Type: GrantFiled: October 20, 1989Date of Patent: September 1, 1992Assignee: A/S Dumex (Dumex Ltd.)Inventors: Pia Lading, Yvonne Lundsholm, Tomas Norling
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Patent number: 5046629Abstract: A container comprising a mouth the outside of said mouth comprising an external thread covering only part of the periphery of the mouth to provide at least one axially extending thread-free zone, a screw cap (2) for onscrewing onto the external thread, the skirt of the screw cap (2) comprising a hole (9) and means for preventing an unwanted unscrewing of the screw cap (2) said means consisting of an element (5) which is hinge-connected to the exterior side of the screw cap (2), said element can be swung over and be engaged with the free end of the screw cap, and said element has a projection (12) which extends through the hole (9) and ends in the thread-free zone when the screw cap (2) is in its closing position.Type: GrantFiled: September 25, 1990Date of Patent: September 10, 1991Assignee: A/S DumexInventor: Charlotte Weile
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Patent number: 4482722Abstract: N,N-dimethylglycine ester of metronidazole, acid addition salt thereof and method of preparing such ester or acid addition salt. The novel compounds exhibit favorable solubility in water and are especially useful for the parenteral treatment of certain anaerobic infections.Type: GrantFiled: June 8, 1983Date of Patent: November 13, 1984Assignee: A/S Dumex (Dumex Ltd.)Inventors: Pia Thorbek, Hans Bundgaard, Claus Larsen
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Patent number: 4424229Abstract: Fluorosubstituted benzaldehydes are condensed with anisil and ammonium acetate to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)imidazoles. Alternatively fluorosubstituted benzaldehydes are condensed with anisil monoxime and ammonium acetate to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)-imidazole-3-oxides which can subsequently be reduced to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)imidazoles. These imidazoles have interesting pharmacological properties.Type: GrantFiled: March 10, 1982Date of Patent: January 3, 1984Assignee: A/S Dumex (Dumex Ltd.)Inventors: Dan Jorgensen, Hjarne Dyrsting
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Patent number: 4396610Abstract: New guanidine derivatives of polyene macrolides having at least one free amino group and at least one free carboxy group (e.g. nystatin, pimaricin, amphotericin B, candicidin and trichomycin) are prepared by reacting the macrolide with a carbodiimide of the formula:R.sup.1 --N.dbd.C.dbd.N--R.sup.2wherein R.sup.1 and R.sup.2 are independently alkyl, substituted alkyl, cycloalkyl, aralkyl, aryl or aroylalkyl. Esters and salts of the derivatives can also be formed. The new derivatives are water-soluble and can be used as anti-mycotic agents.Type: GrantFiled: December 23, 1980Date of Patent: August 2, 1983Assignee: A/S Dumex (Dumex Ltd.)Inventor: Niels Witzke
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Patent number: 3952005Abstract: Imidazole derivatives substituted in the 1-position by a carboxyalkyl group or an ester of a such and the acid addition salts thereof, and where possible the alkali metal and alkaline earth metal salts thereof possess good antiphlogistic and analgesic activities. Such compounds are prepared, for example, by introducing the carboxyalkyl group or an ester of a such into the 1-position of a corresponding imidazole derivative unsubstituted in the 1-position. Alternatively such compounds are prepared by reacting an appropriate keto-oxime with an appropriate amino compound and an appropriate aldehyde or acetal and optionally reducing the imidazole derivative thus obtained.Type: GrantFiled: June 27, 1974Date of Patent: April 20, 1976Assignee: A/S DumexInventor: Dan Jorgensen
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Patent number: D360684Type: GrantFiled: June 2, 1993Date of Patent: July 25, 1995Assignee: A/S Dumex (Dumex Ltd.)Inventor: Jorn Ronvig