Abstract: Sterilized, preserved, stable mucine-containing solutions for use for application to sensitive human mucous membranes of the oral cavity, the nasal system, and the eye ephithel contain an oxidizing bactericide, in particular hydrogen peroxide, as preservative. Even at very small hydrogen peroxide concentrations, solutions remain bactericidal over prolonged periods such as 1-2 years. Mucine used is porcine gastric mucine or bovine salivary mucine or--to adjust the polar/non-polar properties--a mixture of both.The pronounced lubricating effect, combined with suitable viscosity, low surface tension and ability to coat and protect mucous membranes renders the solutions well suited as artificial salivas, ophthalmic solutions, and carriers for medicaments.
Type:
Grant
Filed:
December 28, 1981
Date of Patent:
March 20, 1984
Assignee:
A/S Orthana Kemisk Fabrik
Inventors:
Erik Balslev, Svenn S. Hansen, Ernst L. Pedersen
Abstract: A method and apparatus for making basic or starting material for the production of a biologically active preparation such as pepsin and/or mucin from stomachs of swines or hogs. The starting material is made by mechanically separating mucous cells from their supporting membrane at the fundus regions of the stomachs without substantially damaging said membrane, the mucous cells may, for example, be separated by cutting, abrading, or scraping action. The stomachs are preferably suspended at their thicker edge portions while they are treated by one or more pairs of oppositely rotating rollers having scraping edges thereon such as flexible fingers or knobs. The invention also relates to a basic material produced by the said method and substantially consisting of mucous cells separated from the membranes at the fundus region of stomachs of swines or hogs.