Abstract: The present invention relates to novel substituted azetidine dihydrothienopyridines with phosphodiesterase inhibitory activity, and to their use in therapy, and to pharmaceutical compositions comprising the compounds and to methods of treating diseases with the compounds (I)

Abstract: The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.

Abstract: Disclosed is a method for controlling an auto injector and an auto injector for administering a medicament from a cartridge having a first cartridge end and a second cartridge end and having a cartridge outlet at the first cartridge end, the cartridge comprising a cartridge compartment with a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament. The auto injector comprises: a housing; a cartridge receiver; a cartridge sensor; a drive module; an orientation sensor; and a processing unit.

Abstract: Process for producing an ambient storage food product comprising providing a food product with a pH of between 3.4 and 4.4, subjecting the food product to a heat treatment to obtain a heat treated food product, adding aseptically to the heat treated food product one or more of ambient storage lactic acid bacteria strains to obtain an ambient storage food product, and storing the ambient storage food product at ambient temperature for a period of time, wherein the ambient storage lactic acid bacteria strain is selected from the group consisting of strains, (i) wherein the strain is capable of retaining viability at the end of 150 days at a temperature of 25#C, and (ii) wherein the pH at most decreases 0.8 units during the storage period, and (iii) wherein the strain is selected from the group consisting of Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus fermentum and Lactobacillus delbrueckii subsp. bulgaricus, and mutants and variants thereof.

Abstract: Disclosed is a wind turbine blade comprising a shell body, a down conductor arranged in the shell body for conducting lightning current to ground, an electrical connector arranged in electrical connection with the down conductor, a lightning receptor element arranged at a surface of the shell body or outside the shell body, the lightning receptor element being in electrical connection with the electrical connector. A method for manufacturing a wind turbine blade with a lightning protection system is also provided.

Abstract: The invention relates to a method for operating a wind turbine which comprises a power generator, a generator side converter, a grid side converter, a DC link electrically connected to an output of the generator side converter and an input of the grid side converter. The method comprises monitoring a wind turbine signal for detection of an operational condition which requires an increase of an output voltage of the grid side converter, upon detection of the operational condition, initiate an over-modulation mode wherein the grid side converter is operated with a modulation index in an over-modulation range, and upon the detection of the operational condition, initiate a DC-voltage adjustment mode wherein the a DC-voltage of the DC link is increased from a first voltage level towards a second voltage level.

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

Abstract: Various embodiments of the present disclosure are directed to carbon dioxide and/or hydrogen sulphide sampling and detection system and method for determination of the content of gaseous CO2 and/or H2S in a liquid, among other chemical compounds. In one embodiment, the detection system includes a membrane block having a liquid sample inlet port and a sample outlet port between which a sample flow path extends. The membrane block includes a first membrane unit and a second membrane unit. The first membrane unit includes a sample flow on the first side of a first permeable membrane element, and a carrier gas flow on the second side of the first permeable membrane element. The second membrane unit having a sample flow on the first side of a second permeable membrane element and a carrier gas flow on the second side of the second permeable membrane element.

Abstract: Provided are methods of clinical treatment of follicular lymphoma (for example, relapsed and/or refractory follicular lymphoma) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of care regimens of rituximab and lenalidomide.

Abstract: A bicycle chain includes a pair of outer plates, a pair of inner plates, and a connecting pin assembly. The pair of outer plates defines a width of the bicycle chain in a transverse direction, and the pair of inner plates is positioned at least partially between the pair of outer plates. The connecting pin assembly connects the pair of outer plates with the pair of inner plates and includes a first rocker pin, a second rocker pin, and a center pin between the first rocker pin and the second rocker pin in a longitudinal direction. A length of the center pin in the transverse direction is less than the width of the bicycle chain.

Abstract: A heli-hoist platform for a wind turbine includes: a deck plate accessible by a worker from a helicopter; a barrier provided along the periphery of the deck plate; and a pair of support brackets extending along a longitudinal direction of the heli-hoist platform at both ends in a width direction of the deck plate.

Abstract: A transcutaneous bone-anchored hearing aid device for a recipient patient is described.

Abstract: Disclosed is a moisture switchable adhesive composition including a polymer and a switch initiator. The composition can be switched from a first liquid state to a second adhesive state by activation of the switch initiator. The composition has in the first liquid state a complex viscosity |?*| below 0.4 MPa s; and the composition has in the second adhesive state a second repeated peel force above 1 N/25 mm.