Abstract: A switching amplifier, such as a Class D amplifier, includes a current sensing circuit. The current sensing circuit is formed by replica loop circuits that are selectively coupled to corresponding output inverter stages of the switching amplifier. The replica loop circuits operated to produce respective replica currents of the output currents generated by the output inverter stages. A sensing circuitry is coupled to receive the replica currents from the replica loop circuits and operates to produce an output sensing signal as a function of the respective replica currents.

Abstract: System and method for use of mixed and augmented reality Imaging surgical suite and an augmented reality device are provided. A 2D/3D virtual grid having a head-up display with augmented reality is provided. The head-up display can display a 2D radiographic image or 3D volumetric representation or shape model of image, and can further display an augmented reality grid/indicator which can be depicted as a grid, implant, instrument or bone avatar/figure representing shapes, orientations, and positions relative to an anatomical image or model. The augmented reality indicator can be displayed directly in a surgeon's field of view to provide a live, intra-operative situational environment and navigational guidance for the surgeon. The head-up display can show avatar grids/indicators that are outside of the surgeon's field of view within a patient's body.

Abstract: The present invention concerns a medical injection device for apportioning set doses of a preservative containing liquid drug. The injection device comprises a housing supporting a cartridge containing the preservative containing liquid drug and a needle cannula for transferring the liquid drug from the cartridge and through the skin of a user. Further, a needle shield which is axially movable in relation to the housing is also present. The axially movable shield carries a cleaning reservoir for cleaning at least the tip of the needle cannula between subsequent injections and the cleaning reservoir is preferably filled with preservative containing liquid drug directly from the cartridge upon initiation of the injection device. In order to eliminate any overpressure being built up inside the cleaning reservoir during the filling process, the cleaning reservoir is provided with an outlet configured to be permanently sealed by a user activated operation.

Abstract: A data system for handling user data for a hearing aid user and at least one hearing aid (10, 11) having a memory for storing personal settings for alleviating a hearing loss for the hearing aid user includes a remote server (25) accessible by means of an Internet enabled computer device. A personal communication device (13) is Internet enabled and is able to act as a gateway to the Internet for the at least one hearing aid. The user may create a user account on the remote server, enter personal information into the user account and store the entered personal information on the remote server, and enter the gateway information to the user account. The personal communication device and the at least one hearing aid are provided with respective transceivers for establishing a wireless connection under guidance of said application software. The least one hearing aid uploads the personal settings for alleviating the hearing loss via the gateway to the remote server for storing in the user account.

Abstract: Combination therapies comprising antibody molecules that specifically bind to LAG-3 are disclosed. The combination therapies can be used to treat, prevent and/or diagnose cancerous or infectious disorders.

Abstract: The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.

Abstract: The invention discloses a device for identifying fluids or measuring their concentration. The device is configured to capture fluid sensing signals and sent to processing capabilities to be annotated, pre-processed and fed to databases of datasets and models which have learning capabilities. The device has a stick or stylus form factor which is makes it fit to be used by health care professionals or by the general public. Advantageously, the stick can be used to capture data from gas and liquid, being possibly phases of the same analyte. The device can be a package containing all processing capabilities being configured to be autonomous. It can operate in conjunction with an intermediary device of a smart phone, a PC or a POCT type. The system comprising autonomous fluid sensory devices, intermediary devices and database servers can operate in a learning mode or in a use mode.

Abstract: An electrical connector comprises a contact-carrying body having a plurality of electrical terminals, a slide member slidably mounted within the contact-carrying body and having a rack, an upper body mounted to the contact-carrying body, and a lever pivotally mounted on the upper body. The lever has a toothed wheel engaging the rack; movement of the lever between an inoperative position and an operative position moves the slide member between a retracted position and an advanced position. The lever has arms and a handle. Each arm of the lever has a telescoping structure including a first arm portion and a second arm portion slidably mounted to the first arm portion and connected to the handle. A movable portion including the second arm portion of each arm and the handle is movable with respect to each of the first arm portions between an elongated lever position and a shortened lever position.

Abstract: The present invention proposes a timepiece mechanism comprising: a lever, rotatable about a lever axis, the angular position of the lever representing a first value, wherein a zero value of the first value corresponds to a reference direction, a sliding block mounted to move in translation on the lever in a direction substantially perpendicular to the axis of the lever and comprising a guide-mark element whose trajectory in translation relative to the lever is secant to the lever axis, the radial position of the guide-mark element with respect to the lever axis representing a second value, an output device formed of a deformable parallelogram in a plane perpendicular to the lever axis, the parallelogram including a first side, which is stationary with reference to the lever axis and perpendicular to the reference direction, a second side, which is opposite to the first side and linked in translation to the guide-mark element in the direction perpendicular to the reference direction, the angular position o

Abstract: A fabric structure includes a first layer, a second layer, and a spacing layer that interconnects the first layer and the second layer, wherein, the interconnecting of the first layer, second layer, and third layer forms a plurality of channels.

Abstract: The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: A preform element, it production and fiber production methods from preform assemblies are disclosed. The preform element has a length and a center axis along its length, a first and second end defined by its length and an outer preform element surface. The preform element comprises a plurality of longitudinal structures disposed to form longitudinal hole(s) in a background material. At least one slot extending from its outer preform element surface and intersecting at least one of the longitudinal holes, wherein the at least one slot does not fully intersect the preform element. The preform element may be a preform center element or a preform ring element and may be assembled to a form part of a preform assembly for an optical fiber.

Abstract: A non-destructive inspection device includes: a probe, a camera configured to film an area of the part inspected by the probe, a first display and a second display system configured to allow a display of at least one image filmed by the camera. This configuration makes it possible to remotely display the area of the part inspected by the probe.

Abstract: According to an embodiment, a hearing aid is disclosed. The hearing aid includes a housing, a light guide member, a first light source, and a second light source. The housing includes electronic components configured to generate a perceivable modulated signal in response to a received sound. The perceivable modulated signal is configured to produce a hearing sensation to a user of the hearing aid. The light guide member is arranged proximal to and/or within the housing. The first light source configured to emit a first colored light and a second light source configured to emit a second colored light. The first light source and the second light source are positioned within the housing and arranged in relation to the light guide member such that a substantial amount of the first colored light and a substantial amount of the second colored light are adapted to travel through the light guide member.

Abstract: A semiconductor device includes a layered package having a semiconductor die embedded therein, the semiconductor die coupled with a thermally-conductive element. The layered package includes, e.g., PCB boards with an intermediate layer having the semiconductor die arranged therein, and a pair of outer layers, with the thermally-conductive element including a thermally-conductive inlay in one of the outer layers.

Abstract: This invention relates to a process for the production of fermentable C5-C6 sugars from oleaginous herbaceous plants comprising the steps of: a) mechanically separating the seeds from the above-ground lignocellulose biomass and breaking-up said lignocellulose biomass; b) placing the above-ground lignocellulose biomass in contact with a basic aqueous solution so as to obtain a paste containing from 10 to 50% by weight of the said lignocellulose biomass at temperature of between 10 and 95° C. for a time of between 1 minute and 24 hours; c) separating out the paste obtained in step b) in a solid fraction containing essentially hemicellulose and cellulose; in a liquid fraction containing lignin and extractables; d) subjecting the said solid fraction containing essentially hemicellulose and cellulose to enzyme hydrolysis.

Abstract: Described herein is a preparation process of a flame retardant composition made from brominated bismuth and/or antimony compounds complexed with melamine, in which melamine, at least one between the bismuth carbonate and antimony sesquioxide, hydrobromic acid in aqueous solution are placed in contact with each other so as to trigger chemical reactions which lead to the formation of a complex of brominated bismuth or brominated antimony with melamine and melamine bromohydrate. The reagents are placed in contact in the presence of at least one reaction carrier defined by at least one compound chosen from the group consisting of melamine, melamine phosphate, melamine polyphosphate, ammonium phosphate, ammonium polyphosphate, triphenyl-phosphate, graphite, silica, lignin, coke and compounds containing triazine rings condensed or linked by —NH groups. The reaction carrier is not involved in the reactions. There are no polymeric compounds in quantities such as to create a polymer matrix.

Abstract: A Raman pumping arrangement for amplifying a data optical signal (40) has a Raman pump (12) for generating a Raman pump signal (44;45), an optical supervisory channel receiver (14) for receiving an optical supervisory channel signal (42) an amplification fiber (15) arranged such that the data optical signal (40), the optical supervisory channel signal (42), and the Raman pump signal (44;45) are transmitted therethrough; and a control unit (13) configured for controlling the operation of the Raman pump (12); wherein the control unit (13) is configured for setting the Raman pump (12) in an operation mode or a start-up mode; wherein in the operation mode, the Raman pump (12) provides an operation pumping power (120), and wherein in the start-up mode, the Raman pump (12) provides a start-up pumping power (122).

Abstract: The present invention relates to a filling device for heterogeneous products or products which have solid or semi-solid suspended elements with variable dimensions and compactness. The valve of the invention can be used in net weight filling machines. In particular, the invention relates to a filling device (1) for filling machines, comprising a hollow body (2) in which a shutter member (3) is movably fitted and acts in cooperation with a dispensing member (4), which is coaxial to said shutter member (3), to close or open a dispensing opening (5) for a product (P) to be dispensed into a container (C), characterized in that said dispensing member (4) comprises a rotatable shaft (10) comprising a screw portion (14) adapted to impart a dispensing pressure and a mixing to the product (P).

Abstract: A new garden rose plant of the Miniature class which has abundant, pink blend flowers and attractive foliage. This new and distinct variety has shown to be uniform and stable in the resulting generations from asexual propagation.