Abstract: A system for facilitating exchange of needles on syringes may include a needle exchange device forming a pair of needle sheaths with each needle sheath defining an insertion opening and a channel in communication with the insertion opening to receive at least a portion of a needle device. One of the needle sheaths may be a dispensing needle sheath for dispensing a needle device to be used for the syringe, another one of the needle sheaths being a disposal needle sheath for receiving a needle device to be disposed. The needle exchange device may be elongated along a longitudinal axis with opposite first and second ends. The system may also include a needle device removably positioned in the dispensing needle sheath. The disposal needle sheath and the dispensing needle sheath may be substantially oppositely oriented on the exchange device.