Abstract: A method is provided for treating pain in patients recovering from post-surgical trauma by administering between about 13 to about 30 mg of diclofenac potassium in a liquid dispersible formulation over a period of at least 24 hours, wherein the daily total amount of diclofenac potassium administered is less than or equal to about 100 mg. The method is particularly useful in treating acute pain in bunionectomy patients.
Type:
Grant
Filed:
February 16, 2010
Date of Patent:
February 7, 2012
Assignee:
Aaipharma Services Corp.
Inventors:
Mark M. Kowalski, James L. Young, Keith A. Moore
Abstract: The present invention provides matrix-forming, sustained-release pharmaceutical formulations comprising four primary components: i) an effective amount of at least one drug substance; ii) at least one pharmaceutically acceptable, water-swellable, pH independent polymer; iii) at least one pharmaceutically-acceptable, anionic, pH dependent polymer; and (iv) a pharmaceutically-acceptable polymer selected from the group consisting of a) at least one pharmaceutically-acceptable cationic polymer; and b) at least one pharmaceutically acceptable hydrocolloid. The present formulations can be used with compounds having a wide range of solubilities as well as compounds characterized as having hydrophobic or hydrophilic characteristics.
Type:
Application
Filed:
December 18, 2009
Publication date:
June 24, 2010
Applicant:
AAIPHARMA SERVICES CORP.
Inventors:
John R. Cardinal, Jack Lawrence James, Elsie Melsopp, David M. Oakley