Abstract: System and method for infectious disease prevention includes transmitting, via a server, a facility credential associated with a facility configured to identify a user operating on an application deployed by server from a mobile computing device. The server receives a user identification test code (UITC) associated with a status of an infectious disease of the user. The server then generates a two-dimensional code associated with the facility credential based on the UITC. The server determines if the two-dimensional code is valid for permitting access to the facility based on the status of the infectious disease. Thereafter, the server activates the two-dimensional code on the mobile computing device for a predetermined period of time. A gatekeeper device responds to the two-dimensional code from the mobile computing device and then permits the user access to the facility within the predetermined period of time based on the facility credential and the two-dimensional code.